{"created":"2024-10-25T07:35:29.009803+00:00","id":2002754,"links":{},"metadata":{"_buckets":{"deposit":"3886d8a2-5e51-430d-9f18-30e359e87378"},"_deposit":{"created_by":7,"id":"2002754","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002754"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002754","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["1114","162","271"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"新規アポトーシス関連タンパク質ヌクリングはNF-κBとSTAT3の調節を介して乳腺退縮を制御する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Nucling Regulates Mammary Gland Involution","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"40","bibliographicPageEnd":"24635","bibliographicPageStart":"24626","bibliographicVolumeNumber":"290","bibliographic_titles":[{"bibliographic_title":" Journal of Biological Chemistry","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Postpartum mammary gland involution is the physiological process by which the lactating gland returns to its pre-pregnant state. In rodent models, the microenvironment of mammary gland involution is sufficient to induce enhanced tumor cell growth, local invasion, and metastasis. Therefore, a deeper understanding of the physiological regulation of involution may provide in-depth information on breast cancer therapy. We herein identified Nucling as an important regulator of involution of the mammary gland. A knock-out mouse model was generated and revealed that postpartum involution were impaired in mice lacking Nucling. Involution is normally associated with an increase in the activation of NF-κB and STAT3, which is required for the organized regulation of involution, and was observed in WT glands, but not in the absence of Nucling. Furthermore, the loss of Nucling led to the suppression of Calpain- 1, IL-6, and C/EBPδ factors, which are known to be essential for normal involution. The number of M2 macrophages, which are crucial for epithelial cell death and adipocyte repopulation after weaning, was also reduced in Nucling-KO glands. Taken together, the results of the present study demonstrated that Nucling played an important role in mammary gland involution by regulating NF-κB and STAT3 signaling pathways.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Biochemistry and Molecular Biology","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":" © the American Society for Biochemistry and Molecular Biology. ","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"1083351X ","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA1202441X","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2883号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-09-24"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文全文の公開:\n内容要旨・審査要旨 : LID201510261009.pdf\n論文全文 : k2883_fulltext.pdf\n著者の申請により要約(2015-10-26公開)に替えて論文全文を公開(2018-12-05)\n本論文は, 著者Huy Van Dangの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1260号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1074/jbc.M115.673848"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1074/jbc.M115.673848","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"305056"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヴァン ダン, フィー","creatorNameLang":"ja"},{"creatorName":"ヴァン ダン, フィー","creatorNameLang":"ja-Kana"},{"creatorName":"Van Dang, Huy","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"坂井, 隆志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1114","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anh Pham, Tuan","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hong Tran, Diem","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"頼田, 和子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宍戸, 裕二","creatorNameLang":"ja"},{"creatorName":"シシド, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Shishido, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"福井, 清","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"271","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-10-26"}],"displaytype":"detail","filename":"LID201510261009.pdf","filesize":[{"value":"233 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002754/files/LID201510261009.pdf"},"version_id":"2269aa8b-e061-41de-b2e9-56d70082d323"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-12-05"}],"displaytype":"detail","filename":"k2883_fulltext.pdf","filesize":[{"value":"3.51 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002754/files/k2883_fulltext.pdf"},"version_id":"cc6d64cb-a735-400b-ad14-4b27bad44256"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NF-κB","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"STAT3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nucling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mammary gland involution","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Nucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Nucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-10-26"},"publish_date":"2015-10-26","publish_status":"0","recid":"2002754","relation_version_is_last":true,"title":["Nucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T07:35:38.520555+00:00"}