{"created":"2024-10-25T07:37:16.772934+00:00","id":2002773,"links":{},"metadata":{"_buckets":{"deposit":"720fbd76-1ccf-4172-a056-e06243e737dd"},"_deposit":{"created_by":7,"id":"2002773","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002773"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002773","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["443","1234","1156","1579","1577","820","1214","591","789","445","269","176"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"グルタミンは抗癌剤起因性腸炎モデルラットの小腸粘膜を保護する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Glutamine protects small intestinal mucosa","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"64","bibliographicPageStart":"59","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Supportive therapy during chemotherapy has become essential, but effective preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model. In this study, we used twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered at 20mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber and oligosaccharide (GFO[○R]) (1000 mg/kg/day) groups. All groups were sacrificed on day 6 and upper jejunums were excised. The jejunal villous height was measured in specimens. IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured. The jejunal villous height was recognized as shorter in the specimen from 5-FU treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase activity in 5-FU+glutamine group were significantly superior to that in 5-FU group (p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity and IgA level in jejunal washing solution showed no significant difference between 5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2742号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-19"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201405131006.pdf\n論文本文 : LID201405281003.pdf\n本論文は，著者Hirokazu Takechiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1203号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.61.59"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.61.59","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"280156"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"武知, 浩和","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬渡, 一諭","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田, 永勝","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"髙橋, 章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中屋, 豊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1577","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"アサクラ, メグミ","creatorNameLang":"ja"},{"creatorName":"アサクラ, メグミ","creatorNameLang":"ja-Kana"},{"creatorName":"Asakura, Megumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中橋, 睦美","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝沢, 宏光","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1214","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"後藤, 正和","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"591","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西野, 豪志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ミナト, タクヤ","creatorNameLang":"ja"},{"creatorName":"ミナト, タクヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Minato, Takuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"古北, 由仁","creatorNameLang":"ja"},{"creatorName":"フルキタ, ヨシヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Furukita, Yoshihito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山本, 洋太","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ユアサ, ヤスヒロ","creatorNameLang":"ja"},{"creatorName":"ユアサ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Yuasa, Yasuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマイ, ヒロミチ","creatorNameLang":"ja"},{"creatorName":"ヤマイ, ヒロミチ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamai, Hiromichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉田, 卓弘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清家, 純一","creatorNameLang":"ja"},{"creatorName":"セイケ, ジュンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Seike, Junichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"丹黒, 章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"176","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-05-13"}],"displaytype":"detail","filename":"LID201405131006.pdf","filesize":[{"value":"180 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002773/files/LID201405131006.pdf"},"version_id":"83fce553-6b1b-4386-825b-af1a87bcb4a3"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-05-28"}],"displaytype":"detail","filename":"LID201405281003.pdf","filesize":[{"value":"590 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002773/files/LID201405281003.pdf"},"version_id":"bfdbbe91-5198-4662-b71f-3a7f2d53b145"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"glutamine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gastrointestinal toxity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anticancer drug","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diamine oxidase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IgA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-01-21"},"publish_date":"2016-01-21","publish_status":"0","recid":"2002773","relation_version_is_last":true,"title":["Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T07:37:25.224594+00:00"}