{"created":"2024-10-25T07:37:40.621769+00:00","id":2002778,"links":{},"metadata":{"_buckets":{"deposit":"709a6987-394e-4eba-a857-0cd7b7978b36"},"_deposit":{"created_by":7,"id":"2002778","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002778"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002778","sets":["1713829974766:1713854681789:1716364516170:1716365540255","1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["1658","508","511","1679"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"歯原性上皮細胞におけるCtip2によるSp6遺伝子の転写制御","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Role of Ctip2 in Sp6 regulation","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"136","bibliographicPageStart":"126","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tooth development relies on the interaction between the oral ectoderm and underlying mesenchyme, and is regulated by a complex genetic cascade. This transcriptional cascade is regulated by the spatiotemporal activation and deactivation of transcription factors.The specificity proteins 6 (Sp6) and chicken ovalbumin upstream promoter transcription factor-interacting protein 2 (Ctip2) were identified in loss-of-function studies as key transcription factors required for tooth development. Ctip2 binds to the Sp6 promoter in vivo ; however, its role in Sp6 expression remains unclear. In this study, we investigated Sp6 transcriptional regulation by Ctip2. Immunohistochemical analysis revealed that Sp6 and Ctip2 colocalize in the rat incisor during tooth development. We examined whether Ctip2 regulates Sp6 promoter activity in dental epithelial cells. Cotransfection experiments using serial Sp6 promoter-luciferase constructs and Ctip2 expression plasmids showed that Ctip2 significantly suppressed the Sp6 second promoter activity, although the Sp6 first promoter activity was unaffected. Ctip2 was able to bind to the proximal region of the Sp6 first promoter, as previously demonstrated, and also to the novel distal region of the first, and second promoter regions. Our findings indicate that Ctip2 regulates Sp6 gene expression through direct binding to the Sp6 second promoter region.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2859号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-09-16"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨 : LID201509181010.pdf\n審査要旨 : LID201509181011.pdf\n論文本文 : LID201509181012.pdf\n本論文は，著者Arya Adiningratの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 :  徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第398号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.61.126"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.61.126","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"277120"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"アディニンラト, アリヤ","creatorNameLang":"ja"},{"creatorName":"アディニンラト, アリヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Adiningrat, Arya","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"谷村, 綾子","creatorNameLang":"ja"},{"creatorName":"タニムラ, アヤコ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanimura, Ayako","creatorNameLang":"en"}],"familyNames":[{"familyName":"谷村","familyNameLang":"ja"},{"familyName":"タニムラ","familyNameLang":"ja-Kana"},{"familyName":"Tanimura","familyNameLang":"en"}],"givenNames":[{"givenName":"綾子","givenNameLang":"ja"},{"givenName":"アヤコ","givenNameLang":"ja-Kana"},{"givenName":"Ayako","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"511","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10610199","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10610199"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"三好, 圭子","creatorNameLang":"ja"},{"creatorName":"ミヨシ, ケイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyoshi, Keiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"三好","familyNameLang":"ja"},{"familyName":"ミヨシ","familyNameLang":"ja-Kana"},{"familyName":"Miyoshi","familyNameLang":"en"}],"givenNames":[{"givenName":"圭子","givenNameLang":"ja"},{"givenName":"ケイコ","givenNameLang":"ja-Kana"},{"givenName":"Keiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1679","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60362/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60362/profile-ja.html"},{"nameIdentifier":"20304537","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20304537"}]},{"creatorNames":[{"creatorName":"Yanuaryska, Ryna Dwi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハギタ, ヒロコ","creatorNameLang":"ja"},{"creatorName":"ハギタ, ヒロコ","creatorNameLang":"ja-Kana"},{"creatorName":"Hagita, Hiroko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"堀口, 大吾","creatorNameLang":"ja"},{"creatorName":"ホリグチ, タイゴ","creatorNameLang":"ja-Kana"},{"creatorName":"Horiguchi, Taigo","creatorNameLang":"en"}],"familyNames":[{"familyName":"堀口","familyNameLang":"ja"},{"familyName":"ホリグチ","familyNameLang":"ja-Kana"},{"familyName":"Horiguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"大吾","givenNameLang":"ja"},{"givenName":"タイゴ","givenNameLang":"ja-Kana"},{"givenName":"Taigo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"508","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"22754/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/22754/profile-ja.html"},{"nameIdentifier":"70304532","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70304532"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"野間, 隆文","creatorNameLang":"ja"},{"creatorName":"ノマ, タカフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Noma, Takafumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"野間","familyNameLang":"ja"},{"familyName":"ノマ","familyNameLang":"ja-Kana"},{"familyName":"Noma","familyNameLang":"en"}],"givenNames":[{"givenName":"隆文","givenNameLang":"ja"},{"givenName":"タカフミ","givenNameLang":"ja-Kana"},{"givenName":"Takafumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1658","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60320/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60320/profile-ja.html"},{"nameIdentifier":"40189428","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40189428"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-09-19"}],"displaytype":"detail","filename":"LID201509181010.pdf","filesize":[{"value":"69.8 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002778/files/LID201509181010.pdf"},"version_id":"092ee7bf-7f03-4112-b22a-6b7e35732dcc"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-09-19"}],"displaytype":"detail","filename":"LID201509181011.pdf","filesize":[{"value":"386 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2002778/files/LID201509181011.pdf"},"version_id":"f3529d80-e262-4fe0-a0f5-d6da7888f22e"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-09-19"}],"displaytype":"detail","filename":"LID201509181012.pdf","filesize":[{"value":"1.66 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002778/files/LID201509181012.pdf"},"version_id":"b4c3b222-c028-4b01-89d6-5fdbc47c00a1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ameloblast differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ctip2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sp6","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tooth development","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transcriptional regulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Ctip2-mediated Sp6 transcriptional regulation in dental epithelium-derived cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ctip2-mediated Sp6 transcriptional regulation in dental epithelium-derived cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148","1716365540255"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-01-25"},"publish_date":"2016-01-25","publish_status":"0","recid":"2002778","relation_version_is_last":true,"title":["Ctip2-mediated Sp6 transcriptional regulation in dental epithelium-derived cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T05:56:29.734963+00:00"}