{"created":"2024-10-25T07:41:31.927235+00:00","id":2002828,"links":{},"metadata":{"_buckets":{"deposit":"db5c68c4-654c-4857-abe6-55a1639c5de6"},"_deposit":{"created_by":7,"id":"2002828","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002828"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002828","sets":["1713829974766:1713854681789:1716364516170:1716365539922","1713853213384:1713853295607"]},"author_link":["1196","324"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"352","bibliographicPageStart":"345","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Buckwheat powder or protein has been shown to decrease the total serum cholesterol level in non-diabetic mice or rats. However, the lipid-lowering effect of buckwheat bran extract (BBE) in diabetic mice has not been fully elucidated. KK-Ay mice that received six-week treatment with BBE showed decreased body weight and liver weight compared to those of control (vehicle) mice. However, there was no significant difference in food intake. BBE treatments prevented liver triglyceride accumulation and decreased the serum level of triglycerides. In addition, mRNA expression levels lipogenic enzyme genes, fatty acid synthase, acetyl-coenzyme a oxidase and stearyl-coenzyme a desaturase 1, but not those of β-oxidized enzyme genes, were decreased in BBE-treated mice. Level of transcription factors ChREBP and SREBP1c, transcripts of lipogenic genes, were also decreased in BBE-treated mice. These results suggest that chronic treatment with BBE derivatives could have beneficial effects on hypertriglycemia in patients with type 2 diabetes mellitus.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"296181"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"保坂, 利男","creatorNameLang":"ja"},{"creatorName":"ホサカ, トシオ","creatorNameLang":"ja-Kana"},{"creatorName":"Hosaka, Toshio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ササガ, サヤカ","creatorNameLang":"ja"},{"creatorName":"ササガ, サヤカ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaga, Sayaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマサカ, ユキコ","creatorNameLang":"ja"},{"creatorName":"ヤマサカ, ユキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamasaka, Yukiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニイ, ヨシタカ","creatorNameLang":"ja"},{"creatorName":"ニイ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Nii, Yoshitaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"エダザワ, カズヒロ","creatorNameLang":"ja"},{"creatorName":"エダザワ, カズヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Edazawa, Kazuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"堤, 理恵","creatorNameLang":"ja"},{"creatorName":"ツツミ, リエ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsutsumi, Rie","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"首藤, 恵泉","creatorNameLang":"ja"},{"creatorName":"シュトウ, エミ","creatorNameLang":"ja-Kana"},{"creatorName":"Shuto, Emi","creatorNameLang":"en"}],"familyNames":[{"familyName":"首藤","familyNameLang":"ja"},{"familyName":"シュトウ","familyNameLang":"ja-Kana"},{"familyName":"Shuto","familyNameLang":"en"}],"givenNames":[{"givenName":"恵泉","givenNameLang":"ja"},{"givenName":"エミ","givenNameLang":"ja-Kana"},{"givenName":"Emi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"324","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10512121","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10512121"}]},{"creatorNames":[{"creatorName":"オカヒサ, ナオキ","creatorNameLang":"ja"},{"creatorName":"オカヒサ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Okahisa, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イワタ, シンヤ","creatorNameLang":"ja"},{"creatorName":"イワタ, シンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, Shinya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"友竹, 浩之","creatorNameLang":"ja"},{"creatorName":"トモタケ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tomotake, Hiroyuki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"酒井, 徹","creatorNameLang":"ja"},{"creatorName":"サカイ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"Sakai, Tohru","creatorNameLang":"en"}],"familyNames":[{"familyName":"酒井","familyNameLang":"ja"},{"familyName":"サカイ","familyNameLang":"ja-Kana"},{"familyName":"Sakai","familyNameLang":"en"}],"givenNames":[{"givenName":"徹","givenNameLang":"ja"},{"givenName":"トオル","givenNameLang":"ja-Kana"},{"givenName":"Tohru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1196","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60693/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60693/profile-ja.html"},{"nameIdentifier":"40274196","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40274196"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-05-26"}],"displaytype":"detail","filename":"LID201605265001.pdf","filesize":[{"value":"663 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002828/files/LID201605265001.pdf"},"version_id":"1388ec7f-78bb-450c-91d3-3829e61afa61"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"buckwheat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"triglyceride","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fatty liver","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lypogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-Ay mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-Ay mice.","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716365539922"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-05-26"},"publish_date":"2016-05-26","publish_status":"0","recid":"2002828","relation_version_is_last":true,"title":["Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-Ay mice."],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-31T05:26:13.749861+00:00"}