{"created":"2024-10-25T07:45:43.821706+00:00","id":2002884,"links":{},"metadata":{"_buckets":{"deposit":"bc4be6d9-2f38-4ee9-9d3f-3ce2a8fd12d9"},"_deposit":{"created_by":7,"id":"2002884","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002884"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002884","sets":["1713853213384:1713853295607"]},"author_link":["1255","1648","1527","1264"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"502","bibliographicPageStart":"499","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Clinical Endocrinology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nRecently, germ-line mutations of aryl hydrocarbon receptor-interacting protein (AIP) gene located on 11q13 were identified in patients with pituitary adenoma predisposition.\nAim/ Patients and Methods\nWe investigated the involvement of the AIP gene in one family with isolated familial somatotropinomas (IFS). To investigate the role of AIP in sporadic GH-secreting adenomas, we first analyzed somatic mutations in 40 tumours. Second, DNA from corresponding leukocytes was analyzed in tumours showing genetic changes of the AIP gene.\nResults\nGerm-line mutation of AIP was found in an IFS family. Biallelic inactivation of AIP by a combination of germ-line mutation and loss of heterozygosity was confirmed in two pituitary adenomas. Mutation analysis of the AIP gene in the 40 sporadic GH-secreting adenomas showed no mutations except for a missense mutation, suggesting that germ-line mutations in patients diagnosed with sporadic acromegaly or gigantism were rare. In a patient with gigantism, a missense mutation of V49M was identified at the germ-line level.\nConclusion\nBased on these results, we conclude that the loss of function of AIP contributes to IFS, but not for most Japanese sporadic GH-secreting adenomas.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Copyright © 1999-2016 John Wiley & Sons, Inc. All Rights Reserved.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"03000664","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00607669","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1111/j.1365-2265.2007.02758.x"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2007.02758.x/pdf","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"162690"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"岩田, 武男","creatorNameLang":"ja"},{"creatorName":"イワタ, タケオ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, Takeo","creatorNameLang":"en"}],"familyNames":[{"familyName":"岩田","familyNameLang":"ja"},{"familyName":"イワタ","familyNameLang":"ja-Kana"},{"familyName":"Iwata","familyNameLang":"en"}],"givenNames":[{"givenName":"武男","givenNameLang":"ja"},{"givenName":"タケオ","givenNameLang":"ja-Kana"},{"givenName":"Takeo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1264","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10350399","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10350399"}]},{"creatorNames":[{"creatorName":"ヤマダ, ショウゾウ","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ショウゾウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Shozo","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"水澤, 典子","creatorNameLang":"ja"},{"creatorName":"ミズサワ, ノリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Mizusawa, Noriko","creatorNameLang":"en"}],"familyNames":[{"familyName":"水澤","familyNameLang":"ja"},{"familyName":"ミズサワ","familyNameLang":"ja-Kana"},{"familyName":"Mizusawa","familyNameLang":"en"}],"givenNames":[{"givenName":"典子","givenNameLang":"ja"},{"givenName":"ノリコ","givenNameLang":"ja-Kana"},{"givenName":"Noriko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1255","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"82856/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/82856/profile-ja.html"},{"nameIdentifier":"80254746","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80254746"}]},{"creatorNames":[{"creatorName":"Hossain, Md. Golam","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐野, 壽昭","creatorNameLang":"ja"},{"creatorName":"サノ, トシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sano, Toshiaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐野","familyNameLang":"ja"},{"familyName":"サノ","familyNameLang":"ja-Kana"},{"familyName":"Sano","familyNameLang":"en"}],"givenNames":[{"givenName":"壽昭","givenNameLang":"ja"},{"givenName":"トシアキ","givenNameLang":"ja-Kana"},{"givenName":"Toshiaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1527","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60040/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60040/profile-ja.html"},{"nameIdentifier":"80154128","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80154128"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"吉本, 勝彦","creatorNameLang":"ja"},{"creatorName":"ヨシモト, カツヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimoto, Katsuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"吉本","familyNameLang":"ja"},{"familyName":"ヨシモト","familyNameLang":"ja-Kana"},{"familyName":"Yoshimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"勝彦","givenNameLang":"ja"},{"givenName":"カツヒコ","givenNameLang":"ja-Kana"},{"givenName":"Katsuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1648","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60308/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60308/profile-ja.html"},{"nameIdentifier":"90201863","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90201863"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-02-29"}],"displaytype":"detail","filename":"LID201602262003.pdf","filesize":[{"value":"192 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002884/files/LID201602262003.pdf"},"version_id":"e59d61c9-41d7-4e42-be60-5338cbffc52a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"isolated familial somatotropinomas","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GH-secreting adenomas","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aryl hydrocarbon receptor-interacting protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The aryl hydrocarbon receptor-interacting protein gene is rarely mutated in sporadic GH-secreting adenomas","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The aryl hydrocarbon receptor-interacting protein gene is rarely mutated in sporadic GH-secreting adenomas","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-02-29"},"publish_date":"2016-02-29","publish_status":"0","recid":"2002884","relation_version_is_last":true,"title":["The aryl hydrocarbon receptor-interacting protein gene is rarely mutated in sporadic GH-secreting adenomas"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T01:10:05.623456+00:00"}