{"created":"2024-10-25T07:46:18.542766+00:00","id":2002891,"links":{},"metadata":{"_buckets":{"deposit":"f4c881ef-9503-44ce-a0d6-a370f4866d07"},"_deposit":{"created_by":7,"id":"2002891","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002891"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002891","sets":["1713853213384:1713853295607"]},"author_link":["1648"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-09-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"42","bibliographicPageEnd":"6183","bibliographicPageStart":"6176","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Oncogene","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Parafibromin is a 531-amino acid protein encoded by HRPT2, a putative tumor suppressor gene recently implicated in the autosomal dominant hyperparathyroidism-jaw tumor familial cancer syndrome and sporadic parathyroid carcinoma. To investigate effects of parafibromin's overexpression on cell proliferation, we performed assays in four different cell lines. The transient overexpression of parafibromin inhibited cell growth in HEK293 and NIH3T3 cells, but enhanced cell growth in the SV40 large T antigen expressing-cell lines such as 293FT and COS7 cells. In 293FT cells, parafibromin was found to interact with SV40 large T antigen and its overexpression promoted entry into the S phase, implying that the interaction enhanced progression through the cell cycle. The tumor suppressor protein parafibromin acts as a positive regulator of cell growth like an oncoprotein in the presence of SV40 large T antigen.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2007 Nature Publishing Group All rights reserved","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09509232","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10687380","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/sj.onc.1210445"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/onc/journal/v26/n42/pdf/1210445a.pdf","subitem_relation_type_select":"URI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"162519"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Iwata, T","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mizusawa, N","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Taketani, Y","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Itakura, M","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"吉本, 勝彦","creatorNameLang":"ja"},{"creatorName":"ヨシモト, カツヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimoto, Katsuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"吉本","familyNameLang":"ja"},{"familyName":"ヨシモト","familyNameLang":"ja-Kana"},{"familyName":"Yoshimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"勝彦","givenNameLang":"ja"},{"givenName":"カツヒコ","givenNameLang":"ja-Kana"},{"givenName":"Katsuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1648","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60308/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60308/profile-ja.html"},{"nameIdentifier":"90201863","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90201863"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-02-29"}],"displaytype":"detail","filename":"LID201602262009.pdf","filesize":[{"value":"1.74 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002891/files/LID201602262009.pdf"},"version_id":"28de3d39-d30b-4106-ba17-b9e2b9e1ee0e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HRPT2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"parafibromin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SV40 large T antigen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumorigenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor suppressor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Parafibromin tumor suppressor enhances cell growth in the cells expressing SV40 large T antigen","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Parafibromin tumor suppressor enhances cell growth in the cells expressing SV40 large T antigen","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-02-29"},"publish_date":"2016-02-29","publish_status":"0","recid":"2002891","relation_version_is_last":true,"title":["Parafibromin tumor suppressor enhances cell growth in the cells expressing SV40 large T antigen"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T01:09:19.399847+00:00"}