{"created":"2024-10-25T07:46:31.469981+00:00","id":2002894,"links":{},"metadata":{"_buckets":{"deposit":"2f2392ab-9019-46af-bdd3-e4bee480432f"},"_deposit":{"created_by":7,"id":"2002894","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002894"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002894","sets":["1713853213384:1713853295607"]},"author_link":["1255","1648","1264","457"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"303","bibliographicPageStart":"297","bibliographicVolumeNumber":"109","bibliographic_titles":[{"bibliographic_title":"Journal of Bioscience and Bioengineering","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Various mechanical stimuli affect differentiation of mesoderm-derived cells such as osteoblasts or myoblasts, suggesting that adipogenesis may be also influenced by mechanical stimulation. However, effects of mechanical stimuli on adipogenesis are\nscarcely known. Compressive force was applied to a human preadipocyte cell line, SGBS. Levels of gene expression were estimated by real-time reverse transcription-polymerase chain reaction. The accumulation of lipids was evaluated by Sudan III or Oil Red O staining. In SGBS cells subjected to a compressive force of 226 Pa for 12 h before adipogenic induction, adipogenesis was inhibited. Compressive force immediately after adipogenic induction did not affect the adipogenesis. The expression　of peroxisome proliferator-activated receptor (PPAR) γ2 and CCAAT/enhancer binding protein (C/EBP) α mRNA during adipogenesis was inhibited by compressive force, whereas C/EBPβ and C/EBPδ mRNA levels were unaffected. In preadipocytes, compressive force increased mRNA levels of Krüppel-like factor 2, preadipocyte factor 1, WNT10b, and cyclooxygenase-2 (COX-2) which are known as negative regulators for the PPARγ2 and C/EBPα genes. Furthermore, a COX-2 inhibitor completely reversed the inhibition of adipogenesis by compressive force. In conclusion, compressive force inhibited adipogenesis by suppressing expression of PPARγ2 and C/EBPα in a COX-2-dependent manner.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2009, The Society for Biotechnology, Japan. All rights reserved.\n© 2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13891723","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11307678","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.jbiosc.2009.09.003"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.sciencedirect.com/science/article/pii/S1389172309009001/pdfft?md5=9a7dba20bbd54cefb1e4ad00e956a3af&pid=1-s2.0-S1389172309009001-main.pdf","subitem_relation_type_select":"URI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"227878"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hossain, Md. 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force","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"preadipocytes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adipogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"COX-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PPARγ2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"C/EBPα","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Compressive force inhibits adipogenesis through COX-2-mediated down-regulation of PPARγ2 and 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