{"created":"2024-10-25T07:46:36.715698+00:00","id":2002895,"links":{},"metadata":{"_buckets":{"deposit":"708ed14a-6465-4aa5-a783-c51672359bc1"},"_deposit":{"created_by":7,"id":"2002895","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002895"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002895","sets":["1713853213384:1713853295607"]},"author_link":["1648","1264"],"control_number":"2002895","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Landscape of FIPA : AIP and Prospective Diagnosis","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"E1254","bibliographicPageStart":"E1242","bibliographicVolumeNumber":"100","bibliographic_titles":[{"bibliographic_title":"The Journal of Clinical Endocrinology & Metabolism","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Context: Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete penetrance. Clinical screening of apparently unaffected AIP mutation (AIPmut) carriers could identify previously unrecognized disease.\nObjective: To determine the AIP mutational status of FIPA and young pituitary adenoma patients, analyzing their clinical characteristics, and to perform clinical screening of apparently unaffected AIPmut carrier family members.\nDesign: This was an observational, longitudinal study conducted over 7 years.\nSetting: International collaborative study conducted at referral centers for pituitary diseases.\nParticipants: FIPA families (n = 216) and sporadic young-onset (≤30 y) pituitary adenoma patients (n = 404) participated in the study.\nInterventions: We performed genetic screening of patients for AIPmuts, clinical assessment of their family members, and genetic screening for somatic GNAS1 mutations and the germline FGFR4 p.G388R variant.\nMain Outcome Measure(s): We assessed clinical disease in mutation carriers, comparison of characteristics of AIPmut positive and negative patients, results of GNAS1, and FGFR4 analysis.\nResults: Thirty-seven FIPA families and 34 sporadic patients had AIPmuts. Patients with truncating AIPmuts had a younger age at disease onset and diagnosis, compared with patients with nontruncating AIPmuts. Somatic GNAS1 mutations were absent in tumors from AIPmut-positive patients, and the studied FGFR4 variant did not modify the disease behavior or penetrance in AIPmut-positive individuals.Atotal of 164 AIPmut-positive unaffected family members were identified; pituitary disease was detected in 18 of those who underwent clinical screening.\nConclusions: A quarter of the AIPmut carriers screened were diagnosed with pituitary disease, justifying this screening and suggesting a variable clinical course for AIPmut-positive pituitary adenomas.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Endocrine Society","subitem_publisher_language":"en"},{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Copyright © 2015 by the Endocrine Society This article has been published under the terms of the Creative Commons Attribution License (CC-BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"0021972X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"19457197","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00695484","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA1203774X","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"Collaborators : Members of the FIPA consortium are listed at http://www.fipapatients.org/fipaconsortium/."}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1210/jc.2015-1869"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1210/jc.2015-1869","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"298560"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hernández-Ramírez, Laura C.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Gabrovska, Plamena","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Dénes, Judit","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Stals, Karen","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Trivellin, Giampaolo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tilley, Daniel","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ferraù, Francesco","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Evanson, Jane","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ellard, Sian","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Grossman, Ashley B.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Roncaroli, Federico","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Gadelha, Mônica R.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Korbonits, Márta","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"岩田, 武男","creatorNameLang":"ja"},{"creatorName":"イワタ, タケオ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwata, Takeo","creatorNameLang":"en"}],"familyNames":[{"familyName":"岩田","familyNameLang":"ja"},{"familyName":"イワタ","familyNameLang":"ja-Kana"},{"familyName":"Iwata","familyNameLang":"en"}],"givenNames":[{"givenName":"武男","givenNameLang":"ja"},{"givenName":"タケオ","givenNameLang":"ja-Kana"},{"givenName":"Takeo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1264","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10350399","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10350399"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"吉本, 勝彦","creatorNameLang":"ja"},{"creatorName":"ヨシモト, カツヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimoto, 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carriers","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-05-16"},"publish_date":"2016-05-16","publish_status":"0","recid":"2002895","relation_version_is_last":true,"title":["Landscape of familial isolated and young-onset pituitary adenomas : prospective diagnosis in AIP mutation carriers"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T01:09:48.635585+00:00"}