{"created":"2024-10-25T07:49:33.938043+00:00","id":2002928,"links":{},"metadata":{"_buckets":{"deposit":"f68cb78a-95bc-4f54-af62-f0a1ae7403eb"},"_deposit":{"created_by":7,"id":"2002928","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002928"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002928","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["1265","669","217","1143","1536"],"control_number":"2002928","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"花粉曝露室のスギ花粉曝露によりスギ花粉症患者に誘発された鼻粘膜ヒスタミンH1受容体mRNA発現亢進に対する抗ヒスタミン薬の影響","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"187","bibliographicPageStart":"183","bibliographicVolumeNumber":"129","bibliographic_titles":[{"bibliographic_title":"Journal of Pharmacological Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the present study, we examined the effects of antihistamine on the up-regulation of H1R mRNA in the nasal mucosa of patients with pollinosis induced by controlled exposure to pollen using an environmental exposure unit. Out of 20 patients, we designated 14 responders, whose levels of H1R mRNA in the nasal mucosa were increased after the first pollen exposure and excluded 6 non-responders. Accordingly, the first exposure to pollen without treatment significantly induced both nasal symptoms and the upregulation of H1R mRNA in the nasal mucosa of the responders. Subsequently, prophylactic administration of antihistamine prior to the second pollen exposure significantly inhibited both of the above effects in the responders. Moreover, the nasal expression of H1R mRNA before the second pollen exposure in the responders pretreated with antihistamine was significantly decreased, as compared with that before the first pollen exposure without treatment. These findings suggest that antihistamines suppressed histamine-induced transcriptional activation of H1R gene in the nasal mucosa, in addition to their blocking effect against histamine on H1R, resulting in a decrease of nasal symptoms. These findings further suggest that by their inverse agonistic activity, antihistamines suppress the basal transcription of nasal H1R in the absence of histamine in responders.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Pharmacological Society","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Copyright: © 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13478613","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11806667","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12022662","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2953号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-22"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201606071012.pdf\n論文本文 : LID201606071013.pdf\n本論文は，著者Hideyuki Nakagawaの学位論文として提出され，学位審査・授与の対象となっている。"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1286号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.jphs.2015.10.007"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jphs.2015.10.007","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"311106"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"北村, 嘉章","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中川, 英幸","creatorNameLang":"ja"},{"creatorName":"ナカガワ, ヒデユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakagawa, Hideyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"藤井, 達也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"669","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"サコダ, タケマ","creatorNameLang":"ja"},{"creatorName":"サコダ, タケマ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakoda, Takema","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"エノモト, タダオ","creatorNameLang":"ja"},{"creatorName":"エノモト, タダオ","creatorNameLang":"ja-Kana"},{"creatorName":"Enomoto, Tadao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"水口, 博之","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"217","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福井, 裕行","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1143","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武田, 憲昭","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1536","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-06-08"}],"displaytype":"detail","filename":"LID201606071012.pdf","filesize":[{"value":"389 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002928/files/LID201606071012.pdf"},"version_id":"950f2383-0e07-43ff-aa4c-d528c56322d1"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-06-08"}],"displaytype":"detail","filename":"LID201606071013.pdf","filesize":[{"value":"540 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002928/files/LID201606071013.pdf"},"version_id":"01950e5c-b94d-48aa-bd6d-f0c3d3bdcd01"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"histamine H1 receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antihistamines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"allergic rhinitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cedar pollinosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"environmental exposure unit","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-06-09"},"publish_date":"2016-06-09","publish_status":"0","recid":"2002928","relation_version_is_last":true,"title":["Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-11-27T05:50:58.548000+00:00"}