{"created":"2024-10-25T07:49:38.042155+00:00","id":2002929,"links":{},"metadata":{"_buckets":{"deposit":"82977925-2ce9-49ec-9dc6-2a35d6310659"},"_deposit":{"created_by":7,"id":"2002929","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002929"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002929","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["1537","1558"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"5-HT2A/2C受容体アゴニストである1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropaneはセロトニン神経に対するエタノールの神経発生毒性を軽減する","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"DOI mitigates DNT of EtOH to 5-HT cells","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-12-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"171","bibliographicPageStart":"163","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"Congenital Anomalies","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Prenatal ethanol exposure causes the reduction of serotonergic (5-HTergic) neurons in the midbrain raphe nuclei. In the present study, we examined whether an activation of signaling via 5-HT2A and 5-HT2C receptors during the fetal period is able to prevent the reduction of 5-HTergic neurons induced by prenatal ethanol exposure. Pregnant Sprague-Dawley rats were given a liquid diet containing 2.5 to 5.0% (w/v) ethanol on gestational days (GDs) 10 to 20 (Et). As a pair-fed control, other pregnant rats were fed the same liquid diet except that the ethanol was replaced by isocaloric sucrose (Pf). Each Et and Pf group was subdivided into two groups; one of the groups was treated with 1 mg/kg (i.p.) of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), an agonist for 5-HT2A/2C receptors, during GDs 13 to 19 (Et-DOI or Pf-DOI), and another was injected with saline vehicle only (Et-Sal or Pf-Sal). Their fetuses were removed by cesarean section on GD 19 or 20, and fetal brains were collected. An immunohistological examination of 5-HTergic neurons in the fetuses on embryonic day 20 using an antibody against tryptophan hydroxylase revealed that the number of 5-HTergic neurons in the midbrain raphe nuclei was significantly reduced in the Et-Sal fetuses compared to that of the Pf-Sal and Pf-DOI fetuses, whereas there were no significant differences between Et-DOI and each Pf control. Thus, we concluded that the reduction of 5-HTergic neurons that resulted in prenatal ethanol exposure could be alleviated by the enhancement of signaling via 5-HT2A/2C receptors during the fetal period.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Teratology Society","subitem_publisher_language":"en"},{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"17414520","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2954号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201606071014.pdf\n論文本文 : k2954_fulltext.pdf\n著者の申請により要約(2016-06-07公開)に替えて論文全文を公開(2018-06-14)\n本論文は, 著者Tsukasa Ishiguroの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1287号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1111/cga.12152"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/cga.12152","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"317981"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石黒, 司","creatorNameLang":"ja"},{"creatorName":"イシグロ, ツカサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishiguro, Tsukasa","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"坂田, ひろみ","creatorNameLang":"ja"},{"creatorName":"サカタ, ヒロミ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakata-Haga, Hiromi","creatorNameLang":"en"}],"familyNames":[{"familyName":"坂田","familyNameLang":"ja"},{"familyName":"サカタ","familyNameLang":"ja-Kana"},{"familyName":"Sakata-Haga","familyNameLang":"en"}],"givenNames":[{"givenName":"ひろみ","givenNameLang":"ja"},{"givenName":"ヒロミ","givenNameLang":"ja-Kana"},{"givenName":"Hiromi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1558","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50294666","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50294666"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"福井, 義浩","creatorNameLang":"ja"},{"creatorName":"フクイ, ヨシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukui, Yoshihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"福井","familyNameLang":"ja"},{"familyName":"フクイ","familyNameLang":"ja-Kana"},{"familyName":"Fukui","familyNameLang":"en"}],"givenNames":[{"givenName":"義浩","givenNameLang":"ja"},{"givenName":"ヨシヒロ","givenNameLang":"ja-Kana"},{"givenName":"Yoshihiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1537","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60050/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60050/profile-ja.html"},{"nameIdentifier":"50144168","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50144168"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-06-07"}],"displaytype":"detail","filename":"LID201606071014.pdf","filesize":[{"value":"336 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002929/files/LID201606071014.pdf"},"version_id":"eb84e25e-ebdb-4730-8e90-931404fef6bd"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-06-14"}],"displaytype":"detail","filename":"k2954_fulltext.pdf","filesize":[{"value":"1.02 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002929/files/k2954_fulltext.pdf"},"version_id":"aa57cca2-d9a3-46ef-a4db-4708b1f23da1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fetal ethanol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"5-HTergic neuron","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Midbrain raphe nuclei","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A 5-HT2A/2C receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, mitigates developmental neurotoxicity of ethanol to serotonergic neurons","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A 5-HT2A/2C receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, mitigates developmental neurotoxicity of ethanol to serotonergic neurons","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-06-09"},"publish_date":"2016-06-09","publish_status":"0","recid":"2002929","relation_version_is_last":true,"title":["A 5-HT2A/2C receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, mitigates developmental neurotoxicity of ethanol to serotonergic neurons"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-14T00:30:21.345581+00:00"}