{"created":"2024-10-25T09:39:59.528287+00:00","id":2002939,"links":{},"metadata":{"_buckets":{"deposit":"5a69b372-d20a-4423-97f4-489971a8b361"},"_deposit":{"created_by":7,"id":"2002939","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002939"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002939","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["1251","323","467"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Smad3の欠損はS1P/S1P3シグナル経路を介して下顎頭軟骨変性を生じる","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Chondrocyte Migration Mediated by Smad3/S1P3","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"2756","bibliographicPageStart":"2742","bibliographicVolumeNumber":"185","bibliographic_titles":[{"bibliographic_title":"The American Journal of Pathology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Temporomandibular joint osteoarthritis is a degenerative disease that is characterized by permanent cartilage destruction. Transforming growth factor (TGF)-β is one of the most abundant cytokines in the bone matrix and is shown to regulate the migration of osteoprogenitor cells. It is hypothesized that TGF-β/Smad3 signaling affects cartilage homeostasis by influencing sphingosine 1-phosphate (S1P)/ S1P receptor signaling and chondrocyte migration. We therefore investigated the molecular mechanisms by which crosstalk may occur between TGF-β/Smad3 and S1P/S1P receptor signaling to maintain condylar cartilage and to prevent temporomandibular joint osteoarthritis. Abnormalities in the condylar subchondral bone, including dynamic changes in bone mineral density and microstructure, were observed in Smad3-/- mice by microcomputed tomography. Cell-free regions and proteoglycan loss characterized the cartilage degradation present, and increased numbers of apoptotic chondrocytes and matrix metalloproteinase 13+ chondrocytes were also detected. Furthermore, expression of S1P receptor 3 (S1P3), but not S1P1 or S1P2, was significantly down-regulated in the condylar cartilage of Smad3-/- mice. By using RNA interference technology and pharmacologic tools, S1P was found to transactivate Smad3 in an S1P3/TGF-β type II receptor-dependent manner, and S1P3 was found to be required for TGF-β-induced migration of chondrocyte cells and downstream signal transduction via Rac1, RhoA, and Cdc42. Taken together, these results indicate that the Smad3/S1P3 signaling pathway plays an important role in the pathogenesis of temporomandibular joint osteoarthritis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Investigative Pathology","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00029440","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00520990","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12024839","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2940号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨 : LID201606141004.pdf\n審査要旨 : LID201606141005.pdf\n論文全文 : k2940_fulltext.pdf\n著者の申請により要約(2016-06-15公開)に替えて論文全文を公開(2019-06-05)\n本論文は, 著者Hiroki Moriの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第405号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.ajpath.2015.06.015"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.ajpath.2015.06.015","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"295928"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"森, 大樹","creatorNameLang":"ja"},{"creatorName":"モリ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Mori, Hiroki","creatorNameLang":"en"}],"familyNames":[{"familyName":"森","familyNameLang":"ja"},{"familyName":"モリ","familyNameLang":"ja-Kana"},{"familyName":"Mori","familyNameLang":"en"}],"givenNames":[{"givenName":"大樹","givenNameLang":"ja"},{"givenName":"ヒロキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"467","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"213046/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/213046/profile-ja.html"},{"nameIdentifier":"70448330","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70448330"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"井澤, 俊","creatorNameLang":"ja"},{"creatorName":"イザワ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Izawa, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"井澤","familyNameLang":"ja"},{"familyName":"イザワ","familyNameLang":"ja-Kana"},{"familyName":"Izawa","familyNameLang":"en"}],"givenNames":[{"givenName":"俊","givenNameLang":"ja"},{"givenName":"タカシ","givenNameLang":"ja-Kana"},{"givenName":"Takashi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1251","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30380017","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30380017"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"田中, 栄二","creatorNameLang":"ja"},{"creatorName":"タナカ, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Eiji","creatorNameLang":"en"}],"familyNames":[{"familyName":"田中","familyNameLang":"ja"},{"familyName":"タナカ","familyNameLang":"ja-Kana"},{"familyName":"Tanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"栄二","givenNameLang":"ja"},{"givenName":"エイジ","givenNameLang":"ja-Kana"},{"givenName":"Eiji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"323","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"174876/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/174876/profile-ja.html"},{"nameIdentifier":"40273693","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40273693"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-06-15"}],"displaytype":"detail","filename":"LID201606141004.pdf","filesize":[{"value":"131 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002939/files/LID201606141004.pdf"},"version_id":"450a1d86-2d78-45c0-b0fc-3c38268ebc0f"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-06-15"}],"displaytype":"detail","filename":"LID201606141005.pdf","filesize":[{"value":"515 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2002939/files/LID201606141005.pdf"},"version_id":"547c0b2d-5f92-4628-b1b4-3fb4c389f3d8"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-06-05"}],"displaytype":"detail","filename":"k2940_fulltext.pdf","filesize":[{"value":"4.25 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002939/files/k2940_fulltext.pdf"},"version_id":"1bdbba27-73aa-43da-a7f9-8766851ce4dd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TMJ-OA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Smad3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"S1P","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"migration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"S1P3","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Smad3 Deficiency Leads to Mandibular Condyle Degradation via the Sphingosine 1-Phosphate (S1P)/S1P3 Signaling Axis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Smad3 Deficiency Leads to Mandibular Condyle Degradation via the Sphingosine 1-Phosphate (S1P)/S1P3 Signaling Axis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-06-15"},"publish_date":"2016-06-15","publish_status":"0","recid":"2002939","relation_version_is_last":true,"title":["Smad3 Deficiency Leads to Mandibular Condyle Degradation via the Sphingosine 1-Phosphate (S1P)/S1P3 Signaling Axis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T08:28:55.582719+00:00"}