{"created":"2024-10-25T09:40:25.269621+00:00","id":2002943,"links":{},"metadata":{"_buckets":{"deposit":"406d66d5-96b2-44b3-a772-3bc007884f7b"},"_deposit":{"created_by":7,"id":"2002943","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002943"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002943","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["410","170"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"血管内皮細胞における酸化LDLおよびリゾホスファチジルコリン誘導によるカベオリン-1発現に対するケルセチンおよび代謝物の効果","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"201","bibliographicPageStart":"193","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Oxidized low-density lipoprotein contributes to atherosclerotic plaque formation, and quercetin is expected to exert anti-atherosclerotic effects. We previously reported accumulation of conjugated quercetin metabolites in the aorta of rabbits fed high-cholesterol diets with quercetin glucosides, resulting in attenuation of lipid peroxidation and inhibition of lipid accumulation. Caveolin-1, a major structural protein of caveolae in vascular endothelial cells, plays a role in atherosclerosis development. Here we investigated effects of oxidized low-density lipoprotein, quercetin and its metabolite, quercetin 3-O-β-glucuronide, on caveolin-1 expression. Oxidized low-density lipoprotein significantly upregulated caveolin-1 mRNA expression. An oxidized low-density lipoprotein component, lysophosphatidylcholine, also induced expression of both caveolin-1 mRNA and protein. However, lysophosphatidylcholine did not affect the location of caveolin-1 proteins within caveolae structures. Co-treatment with quercetin or quercetin 3-O-β-glucuronide inhibited lysophosphatidylcholine-induced caveolin-1 expression. Quercetin and quercetin 3-O-β-glucuronide also suppressed expression of adhesion molecules induced by oxidized low-density lipoprotein and lysophosphatidylcholine. These results strongly suggest lysophosphatidylcholine derived from oxidized low-density lipoprotein contributes to atherosclerotic events by upregulating caveolin-1 expression, resulting in induction of adhesion molecules. Quercetin metabolites are likely to exert an anti-atherosclerotic effect by attenuating caveolin-1 expression in endothelial cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Free Radical Research Japan","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2016 Society for Free Radical Research Japan","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"18805086","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"09120009","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10710201","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12091064","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2945号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201606151001.pdf\n論文本文 : LID201608021001.pdf\n著者の申請により要約(2016-06-15公開)に替えて論文本文を公開(2016-08-02)\n本論文は, 著者Chiemi Kamadaの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第233号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3164/jcbn.16-2"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.16-2","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"319370"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鎌田, 智英実","creatorNameLang":"ja"},{"creatorName":"カマダ, チエミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kamada, Chiemi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"向井, 理恵","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"コンドウ, アカリ","creatorNameLang":"ja"},{"creatorName":"コンドウ, アカリ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Akari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サトウ, シンヤ","creatorNameLang":"ja"},{"creatorName":"サトウ, シンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Shinya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"寺尾, 純二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"170","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-06-15"}],"displaytype":"detail","filename":"LID201606151001.pdf","filesize":[{"value":"273 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2002943/files/LID201606151001.pdf"},"version_id":"fd02820e-a437-44fe-aee1-99e02048bde4"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-08-02"}],"displaytype":"detail","filename":"LID201608021001.pdf","filesize":[{"value":"736 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002943/files/LID201608021001.pdf"},"version_id":"e7ac9e5c-0196-47e1-a9fa-777c0ed4b56d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"caveolin-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adhesion molecule","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"quercetin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"quercetin metabolite","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vascular-endothelial cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effect of quercetin and its metabolite on caveolin-1 expression induced by oxidized LDL and lysophosphatidylcholine in endothelial cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of quercetin and its metabolite on caveolin-1 expression induced by oxidized LDL and lysophosphatidylcholine in endothelial cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-06-15"},"publish_date":"2016-06-15","publish_status":"0","recid":"2002943","relation_version_is_last":true,"title":["Effect of quercetin and its metabolite on caveolin-1 expression induced by oxidized LDL and lysophosphatidylcholine in endothelial cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T09:40:36.539758+00:00"}