{"created":"2024-10-25T09:41:48.947822+00:00","id":2002957,"links":{},"metadata":{"_buckets":{"deposit":"0428ca44-5655-4d96-a39f-d2834898f864"},"_deposit":{"created_by":7,"id":"2002957","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2002957"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02002957","sets":["1713829974766:1713854682253:1716422250563:1716423188404","1713853213384:1713853295607"]},"author_link":["1557","1546"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Updated systemic therapy for advanced/metastatic renal cell carcinoma and prostate cancer","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5-6","bibliographicPageEnd":"206","bibliographicPageStart":"201","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"四国医学雑誌","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"As advanced renal cell carcinoma （RCC） shows resistance to anti-cancer drugs, immunotherapy had been the mainstay of systemic therapy. Recently, molecular targeted agents including VEGF and mTOR inhibitors have been introduced, and so systemic therapy for advanced RCC has been significantly altered. VEGF inhibitors show marked efficacy in regard to tumor size reduction, and the representative adverse events include hypertension, hand-foot syndrome, and hypothyroidism. mTOR inhibitors have modest effects for tumor size reduction, and the specific adverse events include stomatitis, hyperglycemia, hyperlipidemia, and interstitial pneumonia. The introduction of molecular targeted agents has improved survival in advanced RCC patients.\nHormonal therapy is at the center of systemic therapy for advanced prostate cancer patients. Castration or LH-RH analogues suppress the proliferation of prostate cancer cells by decreasing androgen production in the testes. Anti-androgens inhibit the binding of testosterone to androgen receptors, and combination therapy of castration or LH-RH analogues and anti-androgens, called maximum androgen blockade, shows enhanced efficacy for advanced prostate cancer. Docetaxel is administered for castration-resistant prostate cancer, and prolongs survival compared to previously used anti-cancer drugs. Regarding new drugs for prostate cancer, an LH-RH antagonist, a CYP17 inhibitor of androgen production in the adrenal glands, and new anti-androgens with a higher affinity for androgen receptors have been developed for clinical use.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"徳島医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00373699","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00102041","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"284555"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 正幸","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金山, 博臣","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1546","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-06-23"}],"displaytype":"detail","filename":"LID201606232001.pdf","filesize":[{"value":"779 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2002957/files/LID201606232001.pdf"},"version_id":"43998234-e172-45b0-a3dc-71f0bbafa75e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"renal cell carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prostate cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"molecular targeted therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hormonal therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"docetaxel","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"腎癌・前立腺癌に対する最新の薬物療法","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腎癌・前立腺癌に対する最新の薬物療法","subitem_title_language":"ja"},{"subitem_title":"ジンガン ゼンリツセンガン ニ タイスル サイシン ノ ヤクブツ リョウホウ","subitem_title_language":"ja-Kana"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716423188404"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-06-23"},"publish_date":"2016-06-23","publish_status":"0","recid":"2002957","relation_version_is_last":true,"title":["腎癌・前立腺癌に対する最新の薬物療法"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T01:36:54.757589+00:00"}