{"created":"2024-10-25T09:46:03.604060+00:00","id":2003015,"links":{},"metadata":{"_buckets":{"deposit":"afe7c0bb-b3b6-48dd-8f28-1189ab379c6e"},"_deposit":{"created_by":7,"id":"2003015","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003015"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003015","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["1196"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"肥満解消のための無作為介入研究による脂肪量とアディポサイトカインの変化","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"146","bibliographicPageStart":"136","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"Diabetes Research : Open Journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adipocytokines arebioactive substances synthesizedand secretedbyfat cell. Previous studies have reported an association between weight loss and adipocytokines. However, these studies are inconsistent and they have not clarified the relationship between weight regain and changes in circulating levels of adipocytokines.\nIn this study, we analyzed the relationship between weight and fat volume changes and adipocytokines. The subjects were 235obese people recruited in the Saku Control Obesity Program (SCOP). Participants were randomly assigned to either immediate (Group A) or delayed (Group B, control group). Group A participants were followed for another two years after completion of the one year intervention. As controls, Group B participants received the same intervention as Group A after a delay of one year. Then they were followed up for one year. The intervention consisted in a one-year lifestyle program to induce weight loss, based on a cognitive-behavioral approach.\nAfter the first year of the study, body weight, BMI, body fat and abdominal fat areas were significantly lower in group A participants, compared to controls. After the intervention, leptin levels were significantly lowered both in men and women. After one year follow-up, both men and women re-gained about 1.5 kg body weight on average. BMI, waist circumference, fat areas by CT and HBA1c significantly increased during the follow-up period. The change of adipocytokine levels by analysis of the quartile of body weight decrease and regain revealed that increased adiponectin and decreased leptin was noteworthy for weight reduction, while increase of leptin influenced the weight regain.\nIn conclusion, our results suggest that leptin could have broad effects on the distribution off at tissues and on lipid metabolism. Leptin inversely associated with adiponectin, which in turn was necessary to decrease body weight. In particular, leptin decreased remarkably in the process of weight reduction, and its increase seemed to be related in weight regain. The observed increase of adiponectin seemed to be induced by reduction in fat volume.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Openventio Publishers","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"23796375","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2961号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-06-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201608021002.pdf\n論文本文 : LID201608021003.pdf\n本論文は, 著者Nobuhisa Kawashimaの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第236号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.17140/DROJ-1-122"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.17140/DROJ-1-122","subitem_relation_type_select":"DOI"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河嶋, 伸久","creatorNameLang":"ja"},{"creatorName":"カワシマ, ノブヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawashima, Nobuhisa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ワタナベ, ショウ","creatorNameLang":"ja"},{"creatorName":"ワタナベ, ショウ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Shaw","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリタ, アケミ","creatorNameLang":"ja"},{"creatorName":"モリタ, アケミ","creatorNameLang":"ja-Kana"},{"creatorName":"Morita, Akemi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アイバ, ナオミ","creatorNameLang":"ja"},{"creatorName":"アイバ, ナオミ","creatorNameLang":"ja-Kana"},{"creatorName":"Aiba, Naomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミヤチ, モトヒコ","creatorNameLang":"ja"},{"creatorName":"ミヤチ, モトヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyachi, Motohiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"酒井, 徹","creatorNameLang":"ja"},{"creatorName":"サカイ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"Sakai, Tohru","creatorNameLang":"en"}],"familyNames":[{"familyName":"酒井","familyNameLang":"ja"},{"familyName":"サカイ","familyNameLang":"ja-Kana"},{"familyName":"Sakai","familyNameLang":"en"}],"givenNames":[{"givenName":"徹","givenNameLang":"ja"},{"givenName":"トオル","givenNameLang":"ja-Kana"},{"givenName":"Tohru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1196","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60693/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60693/profile-ja.html"},{"nameIdentifier":"40274196","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40274196"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-08-02"}],"displaytype":"detail","filename":"LID201608021002.pdf","filesize":[{"value":"250 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2003015/files/LID201608021002.pdf"},"version_id":"ec9d8bfa-0c0a-418b-897c-dbef0035a99a"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-08-02"}],"displaytype":"detail","filename":"LID201608021003.pdf","filesize":[{"value":"600 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003015/files/LID201608021003.pdf"},"version_id":"7621df2b-c854-4430-8395-60465116ac1f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adiponectin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Leptin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biomarker","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RCT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"obesity control","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Human","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Changes of Fat Volume and Adipocytokines by the Randomized Intervention Program for Obesity Control Program (SCOP)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Changes of Fat Volume and Adipocytokines by the Randomized Intervention Program for Obesity Control Program (SCOP)","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-08-02"},"publish_date":"2016-08-02","publish_status":"0","recid":"2003015","relation_version_is_last":true,"title":["Changes of Fat Volume and Adipocytokines by the Randomized Intervention Program for Obesity Control Program (SCOP)"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-31T05:26:12.850430+00:00"}