{"created":"2024-10-25T09:48:27.940821+00:00","id":2003047,"links":{},"metadata":{"_buckets":{"deposit":"5d58de24-dc6b-4ac1-b25e-307950b01b22"},"_deposit":{"created_by":7,"id":"2003047","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003047"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003047","sets":["1713829974766:1713855006533:1716426556947:1716427289289","1713853213384:1713853295607"]},"author_link":["169"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Effects of a Naturally Occurring Mutation in Rat Aquaporin 5 on its Water Channel Functions","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"57","bibliographicPageStart":"51","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"四国歯学会雑誌","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aquaporin (AQP) family in mammals is composed of 13 members (AQP0-12) of\nwater channel proteins. One of them, AQP5, is expressed in the various exocrine glands such as the lachrymal, parotid, and submandibular gland, and also in lung. We found the presence of G>A point mutation at position 308 in the rat AQP5 mRNA as well as the genome DNA. This mutation resulted in replacement of Gly103 with Asp103 in the AQP5 protein molecule, and led to various phenotypic alterations in the salivary gland. The point mutation localized in the 3rd trans-membrane domain, which is remote site from the water pore. As expected, the water permeability of the mutant molecule was almost same as that of the wild type molecule, indicating that the mutation does not affect the water permeability. In the submandibular gland, membrane expression of the mutant molecule was extremely reduced; and the secretion of saliva in the mutant rat was reduced also as compared to the wild-type animals. By confocal immunohistochemistry, an increased association of AQP5 and lysosomal markers, Lamp2 and/or cathepsin D was observed in the cytoplasmic area of acinar cells of mutant rats, implying the accelerated metabolism of the mutant molecule by the lysosomal system.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"四国歯学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09146091","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN10050046","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"242884"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"細井, 和雄","creatorNameLang":"ja"},{"creatorName":"ホソイ, カズオ","creatorNameLang":"ja-Kana"},{"creatorName":"Hosoi, Kazuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"細井","familyNameLang":"ja"},{"familyName":"ホソイ","familyNameLang":"ja-Kana"},{"familyName":"Hosoi","familyNameLang":"en"}],"givenNames":[{"givenName":"和雄","givenNameLang":"ja"},{"givenName":"カズオ","givenNameLang":"ja-Kana"},{"givenName":"Kazuo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"169","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10951/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/10951/profile-ja.html"},{"nameIdentifier":"10049413","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10049413"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-08-25"}],"displaytype":"detail","filename":"LID201608242007.pdf","filesize":[{"value":"7.05 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003047/files/LID201608242007.pdf"},"version_id":"d775c716-d4ac-481d-9059-5a53ba4f2570"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アクアポリン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"水チャネル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"外分泌腺","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子変異","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アクアポリン5自然発生遺伝子変異の水チャネル機能におよぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アクアポリン5自然発生遺伝子変異の水チャネル機能におよぼす影響","subitem_title_language":"ja"},{"subitem_title":"アクアポリン5 シゼン ハッセイ イデンシ ヘンイ ノ ミズ チャネル キノウ ニ オヨボス エイキョウ","subitem_title_language":"ja-Kana"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716427289289"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-08-24"},"publish_date":"2016-08-24","publish_status":"0","recid":"2003047","relation_version_is_last":true,"title":["アクアポリン5自然発生遺伝子変異の水チャネル機能におよぼす影響"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T03:49:59.870142+00:00"}