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But few were known about the disease. HBOC is known as a syndrome that causes breast and ovarian cancer at exceptionally high rate in patients who have genetic mutations in BRCA １ or ２. The population of the Genetic/familial high risk breast and/or ovarian cancer is not low rate even in Japan if compared with the Western population. Important thing is recognize the fact that HBOC is not rare in Japan and perform a screening detailed family history if the patient has family history. We can evaluate the risk by genetic test and offer the preventive strategies like an intensive screening with MRI, chemoprevention and prophylactic mastectomy before the occurrence of cancer for the carrier. Genetic counseling service by the authorized doctor and counselor has been started in our institute. Genetic screening of BRCA１/２ mutation can be taken in Tokushima University Hospital.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"徳島医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00373699","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00102041","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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