{"created":"2024-10-25T09:57:05.370530+00:00","id":2003163,"links":{},"metadata":{"_buckets":{"deposit":"0fe31127-8b4e-4983-ad4e-5f68ec23a394"},"_deposit":{"created_by":7,"id":"2003163","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003163"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003163","sets":["1713829974766:1713854682253:1716422249595:1716422933660","1713853213384:1713853295607"]},"author_link":["756"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"New animal models for the translational study of metabolic syndrome-associated liver diseases","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5-6","bibliographicPageEnd":"120","bibliographicPageStart":"113","bibliographicVolumeNumber":"71","bibliographic_titles":[{"bibliographic_title":"四国医学雑誌","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Metabolic syndrome （MS） is a worldwide healthcare issue and a dominant risk factor for the development of incurable diseases that affect the entire body. The hepatic manifestations of MS include nonalcoholic fatty liver disease （NAFLD） and its progressive variant nonalcoholic steatohepatitis （NASH）. NASH is known to extend into liver cirrhosis and hepatocellular carcinoma （HCC）. To determine the pathogenesis and effective treatment, an excellent animal model of NASH/HCC is required. We recently succeeded to develop two MS associated NASH mice model （TSOD mice and DIAR-MSG mice）. Their clinical course and pathological characters were quite similar to those of human MS-NASH patients. Interestingly, most of them developed HCC in aged,\nwhich pathological and functional characters were identical to those of human HCC. In addition, we established a novel mouse model of HCC based on type １ diabetes （DIAR-nSTZ mice） and reported its histopathological features. To compare these mice models from various aspects, we can highlight specific and useful characters of MS associated liver diseases including hepatocarcinogenesis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"徳島医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00373699","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00102041","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"307054"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"常山, 幸一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"756","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-10-19"}],"displaytype":"detail","filename":"LID201610192005.pdf","filesize":[{"value":"1.15 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003163/files/LID201610192005.pdf"},"version_id":"62b716fa-41c1-4c52-8a8d-e504ba84c50f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"animal model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metabolic syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nonalcoholic steatohepatitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"メタボリックシンドローム関連肝疾患モデル動物の開発と応用 : ヒト病態解析への疾患病理学的アプローチ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"メタボリックシンドローム関連肝疾患モデル動物の開発と応用 : ヒト病態解析への疾患病理学的アプローチ","subitem_title_language":"ja"},{"subitem_title":"メタボリック シンドローム カンレン カンシッカン モデル ドウブツ ノ カイハツ ト オウヨウ : ヒト ビョウタイ カイセキ エノ シッカン ビョウリガクテキ アプローチ","subitem_title_language":"ja-Kana"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716422933660"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-10-19"},"publish_date":"2016-10-19","publish_status":"0","recid":"2003163","relation_version_is_last":true,"title":["メタボリックシンドローム関連肝疾患モデル動物の開発と応用 : ヒト病態解析への疾患病理学的アプローチ"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T01:35:28.640278+00:00"}