{"created":"2024-10-25T09:58:54.151085+00:00","id":2003186,"links":{},"metadata":{"_buckets":{"deposit":"25106be5-ace0-4ec8-8fe0-c3812ff1b0e0"},"_deposit":{"created_by":7,"id":"2003186","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003186"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003186","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["348","1251","458","1695","323"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"骨粗鬆症病態下での骨折創傷治癒に対する副甲状腺ホルモンと低出力超音波の影響","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"PTH and LIPUS on Osteoporotic Fracture Healing","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"2488","bibliographicPageStart":"2480","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":" Annals of Biomedical Engineering","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Osteoporotic fracture has become a major public health problem, and until today, the treatments available are not satisfactory. While there is growing evidence to support the individual treatment of parathyroid hormone (PTH) administration and low-intensity pulsed ultrasound (LIPUS) exposure as respectively systemic and local therapies during osteoporotic fracture healing, their effects have not yet been investigated when introduced concurrently. This study aimed to evaluate the effects of combined treatment with PTH (1–34) and LIPUS on fracture healing in ovariectomized (OVX) rats. Thirty-two, 12-week-old female Sprague–Dawley rats were OVX to induce osteoporosis. After 12 weeks, the rats underwent surgery to create bilateral mid-diaphyseal fractures of proximal tibiae. All animals were randomly divided into 4 groups (n = 8 for each): control group as placebo, PTH group, LIPUS group, and combined group. PTH group had PTH administration at a dose of 30 lg/kg/day for 3 days/week for 6 weeks. LIPUS group received ultrasound 5 days/week for 20 min/day for 6 weeks and combined group had both PTH administration and LIPUS exposure for 6 weeks. Fracture healing was observed weekly by anteroposterior radiography and micro-CT. Five weeks after the fracture, the tibia were harvested to permit histological assessments and at week 6, for mechanical property of the fracture callus. Micro-CT showed that the PTH and combined groups exhibited significantly higher BMD and trabecular bone integrity than control group at weeks 4–6. Radiography, fracture healing score and mean callus area indicated that the combined group revealed better healing processes than the individual groups. Mechanically, bending moment to failure was significantly higher in LIPUS, PTH and combined groups than in control group. These data suggest that the combined treatment of PTH and LIPUS have been shown to accelerate fracture bone healing and enhance bone properties rather than single agent therapy, and may be considered as a treatment remedy for fracture healing in postmenopausal osteoporosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© Biomedical Engineering Society 2016\n","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15739686","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12104111","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2976号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-09-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨 : LID201611141025.pdf\n審査要旨 : LID201611141026.pdf\n論文本文 : k2976_fulltext.pdf\n著者の申請により要約(2016-11-14公開)に替えて論文全文を公開(2019-06-05)\n本論文は, 著者KARIMA Q. MANSJURの学位論文として提出され, 学位審査・授与の対象となっている。\nThis is a post-peer-review, pre-copyedit version of an article published in Annals of Biomedical Engineering.\nThe final authenticated version is available online at https://doi.org/10.1007/s10439-015-1533-y\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第410号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s10439-015-1533-y"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10439-015-1533-y","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"306669"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"マンスル, カリマ クルニア","creatorNameLang":"ja"},{"creatorName":"マンスル, カリマ クルニア","creatorNameLang":"ja-Kana"},{"creatorName":"Mansjur, Karima Qurnia","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"黒田, 晋吾","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井澤, 俊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1251","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田, 有一","creatorNameLang":"ja"},{"creatorName":"マエダ, ユウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Maeda, Yuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐藤, 南","creatorNameLang":"ja"},{"creatorName":"サトウ, ミナミ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Minami","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"渡邉, 佳一郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"堀内, 信也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 栄二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"323","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-11-14"}],"displaytype":"detail","filename":"LID201611141025.pdf","filesize":[{"value":"55 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2003186/files/LID201611141025.pdf"},"version_id":"ba886dc9-f37e-4d7d-8b75-c1945f54736c"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-11-14"}],"displaytype":"detail","filename":"LID201611141026.pdf","filesize":[{"value":"354 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2003186/files/LID201611141026.pdf"},"version_id":"7ae64550-3bf0-4cdb-abf5-12052ab7f024"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2019-06-05"}],"displaytype":"detail","filename":"k2976_fulltext.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003186/files/k2976_fulltext.pdf"},"version_id":"42f4d7d3-9c1a-448c-827e-fece7bbe3191"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Low-intensity pulsed ultrasound","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Parathyroid hormone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoporotic fracture","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone healing","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mechanical stimulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The Effectiveness of Human Prathyroid Hormone and Low-intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Effectiveness of Human Prathyroid Hormone and Low-intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-11-14"},"publish_date":"2016-11-14","publish_status":"0","recid":"2003186","relation_version_is_last":true,"title":["The Effectiveness of Human Prathyroid Hormone and Low-intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T09:59:04.184246+00:00"}