{"created":"2024-10-25T10:00:47.558869+00:00","id":2003203,"links":{},"metadata":{"_buckets":{"deposit":"d247fdb5-b453-40fb-aeeb-c3afa23835ca"},"_deposit":{"created_by":7,"id":"2003203","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003203"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003203","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["949","612","1610","1225","761","1274","365","1583","1578","1585"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"食事中のリンが糖代謝および脂質代謝における効果","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"PHOSPHATE REGULATES GLUCOSE AND LIPID METABOLISM","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"E538","bibliographicPageStart":"E526","bibliographicVolumeNumber":"310","bibliographic_titles":[{"bibliographic_title":"American Journal of Physiology-Endocrinology and Metabolism","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent epidemiological and animal studies have suggested that excess intake of phosphate (Pi) is a risk factor for the progression of chronic kidney disease and its cardiovascular complications. However, little is known about the impact of dietary high Pi intake on the development of metabolic disorders such as obesity and type 2 diabetes. In this study, we investigated the effects of dietary Pi on glucose and lipid metabolism in healthy rats. Male 8-wk-old Sprague-Dawley rats were divided into three groups and given experimental diets containing varying amounts of Pi, i.e., 0.2 [low Pi (LP)], 0.6 [control Pi (CP)], and 1.2% [high Pi (HP)]. After 4 wk, the HP group showed lower visceral fat accumulation compared with other groups, accompanied by a low respiratory exchange ratio (V˙ CO2/V˙ O2) without alteration of locomotive activity. The HP group had lower levels of plasma insulin and nonesterified fatty acids. In addition, the HP group also showed suppressed expression of hepatic lipogenic genes, including sterol regulatory element-binding protein-1c, fatty acid synthase, and acetyl-CoA carboxylase, whereas there was no difference in hepatic fat oxidation among the groups. On the other hand, uncoupling protein (UCP) 1 and peroxisome proliferator-activated receptor-γ coactivator-1α(PGC-1α) expression were significantly increased in the brown adipose tissue (BAT) of the HP group. Our data demonstrated that a high-Pi diet can negatively regulate lipid synthesis in the liver and increase mRNA expression related to lipid oxidation and UCP1 in BAT, thereby preventing visceral fat accumulation. Thus, dietary Pi is a novel metabolic regulator.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The American Physiological Society","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"01931849","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15221555","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00066467","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12004897","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2993号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-09-29"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201611301001.pdf\n論文本文：LID201611301002.pdf\n本論文は, 著者Maerjianghan Abuduliの学位論文として提出され, 学位審査・授与の対象となっている。\n著者の名「瑪尓江汗」の正式な漢字については審査要旨のpdfをご参照ください。\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第238号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1152/ajpendo.00234.2015"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1152/ajpendo.00234.2015","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"306625"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"阿不都力, 瑪尓江汗","creatorNameLang":"ja"},{"creatorName":"アブドリ, マルジャンハン","creatorNameLang":"ja-Kana"},{"creatorName":"Abuduli, Maerjianghan","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大南, 博和","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大谷, 環樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保, 均","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ウエダ, ハルカ","creatorNameLang":"ja"},{"creatorName":"ウエダ, ハルカ","creatorNameLang":"ja-Kana"},{"creatorName":"Ueda, Haruka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"河合, 慶親","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1225","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"増田, 真志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"761","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"(山中)奥村, 仙示","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阪上, 浩","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"365","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 浩範","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武田, 英二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹谷, 豊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1585","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-11-30"}],"displaytype":"detail","filename":"LID201611301001.pdf","filesize":[{"value":"269 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2003203/files/LID201611301001.pdf"},"version_id":"8cb74ab3-6c3e-45a8-91af-504a53a02ca9"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-11-30"}],"displaytype":"detail","filename":"LID201611301002.pdf","filesize":[{"value":"3.75 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003203/files/LID201611301002.pdf"},"version_id":"d1fcd5f5-81f5-4359-9438-804eb26991df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Brown adipose tissue","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dietary phosphate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"energy metabolism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"visceral fat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of dietary phosphate on glucose and lipid metabolism","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of dietary phosphate on glucose and lipid metabolism","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-11-30"},"publish_date":"2016-11-30","publish_status":"0","recid":"2003203","relation_version_is_last":true,"title":["Effects of dietary phosphate on glucose and lipid metabolism"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T10:00:55.998360+00:00"}