{"created":"2024-10-25T10:00:51.777381+00:00","id":2003204,"links":{},"metadata":{"_buckets":{"deposit":"5b1f9dcc-d6b4-4d33-b85e-7e4517c2403c"},"_deposit":{"created_by":7,"id":"2003204","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003204"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003204","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["1558","1537"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"胎生期バルプロ酸曝露によるマウス胚の脊髄神経異常","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Spinal nerve defects by prenatal VPA","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"41","bibliographicPageStart":"35","bibliographicVolumeNumber":"93","bibliographic_titles":[{"bibliographic_title":"Anatomical Science International","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To examine in detail spinal nerve defects induced by prenatal exposure to valproic acid in mice, pregnant ICR mice were subcutaneously injected with a single dose of 400 mg/kg valproic acid on gestational day 6, 7, 8, or 9, and their embryos were observed on gestational day 10. The whole-mount immunostaining using an anti-neurofilament antibody allowed us to identify spinal nerve defects, such as a loss of bundle, anastomosis among bundles arising from adjacent segment, and a disrupted segmental pattern of the dorsal root ganglia, in valproic acid-exposed embryos. The prevalence of spinal nerve defects was the highest in the embryos exposed to valproic acid on gestational day8 among the experimental groups. Then, effects of the administration dose of valproic acid on the prevalence of spinal nerve defects were examined on gestational day 10 and found to be dose-dependently increased. It was noteworthy that all embryos exposed to 600 mg/kg of valproic acid on gestational day 8 suffered spinal nerve defects. Folic acid (3 mg/kg/day) supplementation during gestational day 6 to 10 suppressed the prevalence of valproic acid-induced neural tube defects, which are common malformations in offspring prenatally exposed to valproic acid, but not that of spinal nerve defects.Thus, the spinal nerve defects due to prenatal valproic acid exposure might be induced by mechanisms different from those of neural tube defects. Because spinal nerve defects were predicted to be caused by the disrupted segmental arrangement of the somites and/or that of neural crest cells which was the origin of the dorsal root ganglia and/or abnormal polarity of the somite, this mouse model with spinal nerve defects at high incidence, would be useful to examine the effects of valproic acid on somitogenesis and morphogenesis of somite-associated structures.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Japan","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14476959","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1447073X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11619036","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA1209993X","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2994号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-09-29"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201611161018.pdf\n論文本文 : k2994_fulltext.pdf\n本論文は, 著者Juramt Boldの学位論文として提出され, 学位審査・授与の対象となっている。\nThe final publication is available at Springer via https://doi.org/10.1007/s12565-016-0363-9\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1299号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s12565-016-0363-9"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12565-016-0363-9","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"317984"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ボルド, ジュラムト","creatorNameLang":"ja"},{"creatorName":"ボルド, ジュラムト","creatorNameLang":"ja-Kana"},{"creatorName":"Bold, Juramt","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"坂田, ひろみ","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福井, 義浩","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1537","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-11-16"}],"displaytype":"detail","filename":"LID201611161018.pdf","filesize":[{"value":"349 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2003204/files/LID201611161018.pdf"},"version_id":"89ad2857-087d-4422-9d78-3125e3cc6ab9"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-08-25"}],"displaytype":"detail","filename":"k2994_fulltext.pdf","filesize":[{"value":"746 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thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Spinal nerve defects in mouse embroys prenatally exposed to valproic acid","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Spinal nerve defects in mouse embroys prenatally exposed to valproic acid","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-11-29"},"publish_date":"2016-11-29","publish_status":"0","recid":"2003204","relation_version_is_last":true,"title":["Spinal nerve defects in mouse embroys prenatally exposed to valproic acid"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T10:01:01.418027+00:00"}