{"created":"2024-10-25T10:05:22.432312+00:00","id":2003258,"links":{},"metadata":{"_buckets":{"deposit":"4ad73a26-a51e-4999-94bb-00242181f4b1"},"_deposit":{"created_by":7,"id":"2003258","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003258"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003258","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["702","193","265","1266","517","792","885","887","1253"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Secreted Frizzled-Related Protein-1発現低下は肝内胆管癌において予後不良と関係している","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"350","bibliographicPageStart":"344","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"European Journal of Surgical Oncology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims: Secreted Frizzled-Related Protein-1 (SFRP1) is a well-known negative regulator of the wingless type (Wnt)-β-catenin pathway and its inactivation plays an important role in the development and progression of many cancers. In this study, we aimed to determine the clinical significance of SFRP1 expression in intrahepatic cholangiocarcinoma (IHCC) and to define the relationship to Wnt-β-catenin pathway.\nMethods: Fifty IHCC patients who had liver resection were enrolled in this study. SFRP1 protein expression was examined by immunohistochemistry in tumor tissues. The patients were divided into two groups: SFRP1 positive (n=30) and negative (n=20). Clinicopathological characteristics were analyzed.\nResults: SFRP1 significantly correlated with curability (Cur A, B vs. C, p=0.029); and recurrent pattern (intrahepatic vs. extrahepatic, p=0.010). The negative SFRP1 group had significantly poorer prognosis, and 5-year survival rates were 8.1% of the negative SFRP1 group and 44.6% of the positive SFRP1 group, respectively. Moreover, the disease-free survival rate in the negative SFRP1 group was significantly poorer ( p < 0.001). Multivariate analysis revealed that loss of SFRP1served as an independent prognostic factor in IHCC for both overall (HR, 2.923; 95% CI, 1.30-6.56; p=0.009) and disease-free (HR, 2.631; 95% CI, 1.31-5.27; p＝0.006) survival. In addition, SFRP1 expression negatively correlated to β-catenin expression ( p=0.005).\nConclusions: Those results suggested that the loss of SFRP1 could be a poor prognostic factor for IHCC, through the Wnt-β-catenin pathway.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"07487983","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10516435","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3008号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開：\n内容要旨・審査要旨：LID201704121001.pdf\n論文本文：LID201704121002.pdf\n本論文は, 著者M. Davaadorjの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1312号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.ejso.2016.11.017"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.ejso.2016.11.017","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"330325"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ダバドルジ, マンダハナラン","creatorNameLang":"ja"},{"creatorName":"ダバドルジ, マンダハナラン","creatorNameLang":"ja-Kana"},{"creatorName":"Davaadorj, Mandakhnaran","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"齋藤, 裕","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森根, 裕二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池本, 哲也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"居村, 暁","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"髙須, 千絵","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 眞一郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"寺奥, 大貴","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉川, 雅登","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 光生","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1253","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-04-12"}],"displaytype":"detail","filename":"LID201704121001.pdf","filesize":[{"value":"338 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2003258/files/LID201704121001.pdf"},"version_id":"07ead522-9277-4f21-a033-a4a7751d42e3"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-04-12"}],"displaytype":"detail","filename":"LID201704121002.pdf","filesize":[{"value":"1.19 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003258/files/LID201704121002.pdf"},"version_id":"727a34aa-2dea-483b-899a-b4df5cc23e96"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Intrahepatic cholangiocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prognostic factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SFRP1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-Catenin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Loss of Secreted Frizzled-Related Protein-1 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Loss of Secreted Frizzled-Related Protein-1 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-04-17"},"publish_date":"2017-04-17","publish_status":"0","recid":"2003258","relation_version_is_last":true,"title":["Loss of Secreted Frizzled-Related Protein-1 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T10:05:33.977729+00:00"}