{"created":"2024-10-25T10:05:28.942049+00:00","id":2003259,"links":{},"metadata":{"_buckets":{"deposit":"60901829-8544-4742-bf63-ad3aee10d63f"},"_deposit":{"created_by":7,"id":"2003259","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003259"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003259","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["190","192","1631"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"腎発生におけるプロレニン、プロレニン受容体の役割検討","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Soluble (pro)renin receptor in neonates","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"189","bibliographicPageStart":"183","bibliographicVolumeNumber":"176","bibliographic_titles":[{"bibliographic_title":"European Journal of Pediatrics","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and neonates as well as (P)RR expression in human kidney tissues. Samples were collected from 57 preterm and 67 full-term human neonates. (Pro)renin and s(P)RR levels were measured using enzyme-linked immunosorbent assays. Additionally, we performed an immunohistochemical (IHC) analysis of kidney tissues from neonates and minor glomerular abnormalities in order to assess (P)RR expression in the kidney. Plasma (pro)renin and s(P)RR levels in cord blood were significantly higher in preterm neonates than in full-term neonates. Four weeks after birth, these differences were no longer evident for either plasma (pro)renin or s(P)RR levels between the two groups. Importantly, plasma (pro)renin and s(P)RR levels in cord blood were inversely correlated with gestational age. Furthermore, IHC indicated that renal expression levels of (P)RR in neonates was stronger than that in minor glomerular abnormalities.\nConclusion: (P)RR may play a pivotal role in prenatal renal development in humans.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Berlin Heidelberg","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"03406199","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14321076","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00639676","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11622857","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3013号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開：\n内容要旨・審査要旨：LID201704131003.pdf\n論文本文： k3013_fulltext.pdf\n本論文は, 著者Tomomasa Teradaの学位論文として提出され, 学位審査・授与の対象となっている。\nThe final publication is available at link.springer.com.\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1317号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s00431-016-2820-9"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00431-016-2820-9","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"328313"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"寺田, 知正","creatorNameLang":"ja"},{"creatorName":"テラダ, トモマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Terada, Tomomasa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"漆原, 真樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"190","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"サイジョウ, タカヒコ","creatorNameLang":"ja"},{"creatorName":"サイジョウ, タカヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Saijo, Takahiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中川, 竜二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"香美, 祥二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1631","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-04-14"}],"displaytype":"detail","filename":"LID201704131003.pdf","filesize":[{"value":"351 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2003259/files/LID201704131003.pdf"},"version_id":"e8c762e6-432f-442d-9557-8d78a40aa556"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-12-26"}],"displaytype":"detail","filename":"k3013_fulltext.pdf","filesize":[{"value":"4.93 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003259/files/k3013_fulltext.pdf"},"version_id":"dc4a8a0d-e562-477f-85ce-8686052df4ee"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Renin-angiotensin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gestational age","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cord blood","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Enzyme-linked immunosorbent assay","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"(Pro)renin and (pro)renin receptor expression during kidney development in neonates","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"(Pro)renin and (pro)renin receptor expression during kidney development in neonates","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-04-17"},"publish_date":"2017-04-17","publish_status":"0","recid":"2003259","relation_version_is_last":true,"title":["(Pro)renin and (pro)renin receptor expression during kidney development in neonates"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T10:05:39.089579+00:00"}