{"created":"2024-10-25T10:06:01.275804+00:00","id":2003265,"links":{},"metadata":{"_buckets":{"deposit":"6468db37-841d-432a-9253-a7409499c8ac"},"_deposit":{"created_by":7,"id":"2003265","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003265"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003265","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["296","175","990","1412","781","710","359","349","677","1572","1555","852","1643","287"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"局所進行膵癌に対するゲムシタビン定速静注及びS-1併用化学放射線療法の第Ⅰ/Ⅱ相試験","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"FDR-gem plus S-1 with RT for pancreatic cancer","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"620","bibliographicPageStart":"615","bibliographicVolumeNumber":"76","bibliographic_titles":[{"bibliographic_title":"Cancer Chemotherapy and Pharmacology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: This study was conducted to identify the maximum-tolerated dose (MTD) of fixed-dose-rate gemcitabine (FDR-gem) administered concurrently with S-1 and radical radiation for locally advanced pancreatic cancer (LAPC) and to provide efficacy and safety data.\nMethods: Patients with unresectable pancreatic cancer confined to the pancreatic region were treated with FDR-gem (300-400mg/m2, 5mg/m2/min) on days 1, 8, 22, 29 and 60mg/m2 of S-1 orally on days 1-14, 22-35. A total radiation dose of 50.4 Gy (1.8 Gy/day, 28fractions) was delivered concurrently.\nResults: Twenty-five patients were enrolled; all were evaluable for toxicity assessment. In phase I, eight patients were treated in sequential cohorts of three to five patients per dose level. The MTD was reached at level 2, and dose-limiting toxicities were neutropenia and thrombocytopenia. The recommended doses were 300mg/m2 of gemcitabine and 60mg/m2 of S-1 daily. The overall response rate was 25% and disease control rate (partial response plus stable disease) was 92%. The progression-free survival was 11.0 months. The median overall survival and 1-year survival rate were 16.0 months and 73%, respectively.\nConclusion: The combination of FDR-gem and S-1 with radiation is a feasible regimen that shows favorable antitumor activity with an acceptable safety profile in patients with LAPC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer nature","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"03445704","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14320843","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00598397","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA1161885X","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3028号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開：\n内容要旨・審査要旨：LID201704141008.pdf\n論文本文：k3028_fulltext.pdf\n本論文は, 著者Takahiro Gojiの学位論文として提出され, 学位審査・授与の対象となっている。\nThe final publication is available at link.springer.com.\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1332号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s00280-015-2835-3"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00280-015-2835-3","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"296898"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 敬洋","creatorNameLang":"ja"},{"creatorName":"イケダ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Goji, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"木村, 哲夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮本, 弘志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武原, 正典","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カゲモト, カイゾウ","creatorNameLang":"ja"},{"creatorName":"カゲモト, カイゾウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kagemoto, Kaizo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岡田, 泰行","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡崎, 潤","creatorNameLang":"ja"},{"creatorName":"オカザキ, ジュン","creatorNameLang":"ja-Kana"},{"creatorName":"Okazaki, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカオカ, ヨシフミ","creatorNameLang":"ja"},{"creatorName":"タカオカ, 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直樹","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡久, 稔也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"サトウ, ヤスヒロ","creatorNameLang":"ja"},{"creatorName":"サトウ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Yasuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サガワ, タモツ","creatorNameLang":"ja"},{"creatorName":"サガワ, タモツ","creatorNameLang":"ja-Kana"},{"creatorName":"Sagawa, Tamotsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジカワ, コウジ","creatorNameLang":"ja"},{"creatorName":"フジカワ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujikawa, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐藤, 康史","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"852","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生島, 仁史","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高山, 哲治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"287","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-04-14"}],"displaytype":"detail","filename":"LID201704141008.pdf","filesize":[{"value":"384 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2003265/files/LID201704141008.pdf"},"version_id":"133c6937-0bef-452f-b042-359973fa3cce"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-03-08"}],"displaytype":"detail","filename":"k3028_fulltext.pdf","filesize":[{"value":"211 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gemcitabine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"S-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gemcitabine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radiosensitizer","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A phase I/II study of fixed-dose-rate gemcitabine and S-1 with concurrent radiotherapy for locally advanced pancreatic cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A phase I/II study of fixed-dose-rate gemcitabine and S-1 with concurrent radiotherapy for locally advanced pancreatic cancer","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-05-15"},"publish_date":"2017-05-15","publish_status":"0","recid":"2003265","relation_version_is_last":true,"title":["A phase I/II study of fixed-dose-rate gemcitabine and S-1 with concurrent radiotherapy for locally advanced pancreatic cancer"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T10:06:12.320957+00:00"}