{"created":"2024-10-25T10:10:26.707833+00:00","id":2003309,"links":{},"metadata":{"_buckets":{"deposit":"9eafe5dc-4cbd-4765-ba69-0874861fb08f"},"_deposit":{"created_by":7,"id":"2003309","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003309"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003309","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["1251","674","1252","323"],"control_number":"2003309","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"顎関節におけるHIF-1αの役割","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-10-28","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"281","bibliographicPageStart":"274","bibliographicVolumeNumber":"73","bibliographic_titles":[{"bibliographic_title":"Archives of Oral Biology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease characterized by permanent cartilage loss. Articular cartilage is maintained in a low-oxygen environment. The chondrocyte response to hypoxic conditions involves expression of hypoxia inducible factor 1α (HIF-1α), which induces chondrocytes to increase expression of vascular endothelial growth factor (VEGF). Here, we investigated the role of HIF-1α in mechanical load effects on condylar cartilage and subchondral bone in heterozygous HIF-1α-deficient mice (HIF-1α+/-).\nDesign: Mechanical stress was applied to the TMJ of C57BL/6NCr wild-type (WT) and HIF-1α+/- mice with a sliding plate for 10 days. Histological analysis was performed by HE staining, Safranin-O/Fast green staining, and immunostaining specific for articular cartilage homeostasis.\nResults: HIF-1α+/- mice had thinner cartilage and smaller areas of proteoglycan than WT controls, without and with mechanical stress. Mechanical stress resulted in prominent degenerative changes with increased expression of HIF-1α, VEGF, and the apoptosis factor cleaved Caspase-3 in condylar cartilage.\nConclusion: Our results indicate that HIF-1a may be important for articular cartilage homeostasis and protective against articular cartilage degradation in the TMJ under mechanical stress condition, therefore HIF-1α could be an important new therapeutic target in TMJ-OA.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00039969","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00548457","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA11521918","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3072号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開：\n内容要旨：LID201704251016.pdf\n審査要旨：LID201704251017.pdf\n論文本文：LID201704251018.pdf\n本論文は, 著者Akiko Mino-Okaの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第415号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.archoralbio.2016.10.028"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.archoralbio.2016.10.028","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"321027"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡, 彰子","creatorNameLang":"ja"},{"creatorName":"オカ, アキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Mino-Oka, 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栄二","creatorNameLang":"ja"},{"creatorName":"タナカ, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Eiji","creatorNameLang":"en"}],"familyNames":[{"familyName":"田中","familyNameLang":"ja"},{"familyName":"タナカ","familyNameLang":"ja-Kana"},{"familyName":"Tanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"栄二","givenNameLang":"ja"},{"givenName":"エイジ","givenNameLang":"ja-Kana"},{"givenName":"Eiji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"323","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"174876/profile-ja.html","nameIdentifierScheme":"徳島大学 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degradation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chondrocyte apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Roles of hypoxia inducible factor-1α in the temporomandibular joint","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Roles of hypoxia inducible factor-1α in the temporomandibular joint","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-05-10"},"publish_date":"2017-05-10","publish_status":"0","recid":"2003309","relation_version_is_last":true,"title":["Roles of hypoxia inducible factor-1α in the temporomandibular joint"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-06T06:58:35.823909+00:00"}