{"created":"2024-10-25T10:10:36.729825+00:00","id":2003311,"links":{},"metadata":{"_buckets":{"deposit":"e8f5de20-a092-40ee-afcb-1cda7735e5fd"},"_deposit":{"created_by":7,"id":"2003311","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003311"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003311","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["589"],"control_number":"2003311","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"知覚神経節内の神経伝達物質による痛み情報伝達","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"2917","bibliographicPageStart":"2906","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Toxins","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Copyright: © 2015 Omoto et al ; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20726651","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3075号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文：\n内容要旨：LID201704251022.pdf\n審査要旨：LID201704251023.pdf\n論文本文：LID201704251024.pdf\n本論文は, 著者Katsuhiro Omotoの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第418号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/toxins7082906"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.doi.org/10.3390/toxins7082906","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"297100"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大本, 勝弘","creatorNameLang":"ja"},{"creatorName":"オオモト, カツヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Omoto, Katsuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マルハマ, コウタロウ","creatorNameLang":"ja"},{"creatorName":"マルハマ, コウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Maruhama, Kotaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"テラヤマ, リュウジ","creatorNameLang":"ja"},{"creatorName":"テラヤマ, リュウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Terayama, Ryuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマモト, ユミコ","creatorNameLang":"ja"},{"creatorName":"ヤマモト, ユミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Yumiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツシタ, オサム","creatorNameLang":"ja"},{"creatorName":"マツシタ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"Matsushita, Osamu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"スギモト, トモサダ","creatorNameLang":"ja"},{"creatorName":"スギモト, トモサダ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugimoto, Tomosada","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オグマ, ケイジ","creatorNameLang":"ja"},{"creatorName":"オグマ, ケイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Oguma, Keiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"松香, 芳三","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"589","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-04-25"}],"displaytype":"detail","filename":"LID201704251022.pdf","filesize":[{"value":"74 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2003311/files/LID201704251022.pdf"},"version_id":"22857b86-dd97-40f5-a8de-bc8ee506f62a"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-04-25"}],"displaytype":"detail","filename":"LID201704251023.pdf","filesize":[{"value":"40.2 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ganglion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transmitter release","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-05-10"},"publish_date":"2017-05-10","publish_status":"0","recid":"2003311","relation_version_is_last":true,"title":["Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-04T04:42:46.025875+00:00"}