{"created":"2024-10-25T10:12:03.914946+00:00","id":2003327,"links":{},"metadata":{"_buckets":{"deposit":"3a936837-6d5b-4a1c-bee5-670c1e82a67e"},"_deposit":{"created_by":7,"id":"2003327","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003327"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003327","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["564","531","340","183","444","365","501","309"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"肥満によって遊離する脂肪細胞由来のDNA断片が脂肪組織の炎症とインスリン抵抗性を引き起こす","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"e1501332","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"Science Advances","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying mechanism remains largely unknown. Here we showed that obesity-related adipocyte degeneration causes release of cell-free DNA (cfDNA), which promotes macrophage accumulation in adipose tissue via Toll-like receptor 9 (TLR9), originally known as a sensor of exogenous DNA fragments. Fat-fed obese wild-type mice showed increased release of cfDNA, as determined by the concentrations of single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) in plasma. cfDNA released from degenerated adipocytes promoted monocyte chemoattractant protein-1 (MCP-1) expression in wild-type macrophages, but not in TLR9-deficient (Tlr9−/−) macrophages. Fat-fed Tlr9−/− mice demonstrated reduced macrophage accumulation and inflammation in adipose tissue and better insulin sensitivity compared with wild-type mice, whereas bone marrow reconstitution with wild-type bone marrow restored the attenuation of insulin resistance observed in fat-fed Tlr9−/− mice. Administration of a TLR9 inhibitory oligonucleotide to fat-fed wild-type mice reduced the accumulation of macrophages in adipose tissue and improved insulin resistance. Furthermore, in humans, plasma ssDNA level was significantly higher in patients with computed tomography–determined visceral obesity and was associated with homeostasis model assessment of insulin resistance (HOMA-IR), which is the index of insulin resistance. Our study may provide a novel mechanism for the development of sterile inflammation in adipose tissue and a potential therapeutic target for insulin resistance.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for the Advancement of Science","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"2016 © The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"23752548","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3088号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開：\n内容要旨・審査要旨：LID201705191025.pdf\n論文本文：LID201706261002.pdf\n著者の申請により要約(2017-05-19公開)に替えて論文本文を公開(2017-06-26)\n本論文は, 著者Sachiko Nishimotoの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第240号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1126/sciadv.1501332"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1126/sciadv.1501332","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"310765"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西本, 幸子","creatorNameLang":"ja"},{"creatorName":"ニシモト, サチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishimoto, Sachiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"福田, 大受","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ヒガシクニ, ヤストミ","creatorNameLang":"ja"},{"creatorName":"ヒガシクニ, ヤストミ","creatorNameLang":"ja-Kana"},{"creatorName":"Higashikuni, Yasutomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タナカ, キミエ","creatorNameLang":"ja"},{"creatorName":"タナカ, キミエ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Kimie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒラタ, ヨウイチロウ","creatorNameLang":"ja"},{"creatorName":"ヒラタ, ヨウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirata, Yoichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"村田, 知慧","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kim-Kaneyama, Joo-ri","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サトウ, フキコ","creatorNameLang":"ja"},{"creatorName":"サトウ, フキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Fukiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"板東, 正浩","creatorNameLang":"ja"},{"creatorName":"バンドウ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Bando, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"八木, 秀介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"添木, 武","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ハヤシ, テツヤ","creatorNameLang":"ja"},{"creatorName":"ハヤシ, テツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Tetsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"井本, 逸勢","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阪上, 浩","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"365","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島袋, 充生","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐田, 政隆","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"309","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-05-19"}],"displaytype":"detail","filename":"LID201705191025.pdf","filesize":[{"value":"329 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2003327/files/LID201705191025.pdf"},"version_id":"930da87d-fd38-4733-8bb5-80bbbad1feeb"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-06-27"}],"displaytype":"detail","filename":"LID201706261002.pdf","filesize":[{"value":"4.71 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2003327/files/LID201706261002.pdf"},"version_id":"7135a4dd-6736-4a36-81a9-f036afa43c37"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肥満","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"インスリン抵抗性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"慢性炎症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Toll-like receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adipose tissue","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell-free DNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-05-19"},"publish_date":"2017-05-19","publish_status":"0","recid":"2003327","relation_version_is_last":true,"title":["Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-25T10:12:12.246281+00:00"}