{"created":"2024-10-25T10:15:17.436915+00:00","id":2003367,"links":{},"metadata":{"_buckets":{"deposit":"d51a99ac-1c7f-4f88-8b76-ae6ad0776d7b"},"_deposit":{"created_by":7,"id":"2003367","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003367"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003367","sets":["1713853213384:1713853295607"]},"author_link":["424","1721","850","1519"],"control_number":"2003367","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1935","bibliographicPageStart":"1925","bibliographicVolumeNumber":"214","bibliographic_titles":[{"bibliographic_title":"Journal of Experimental Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The chemokine receptor CCR7 directs T cell relocation into and within lymphoid organs, including the migration of developing thymocytes into the thymic medulla. However, how three functional CCR7 ligands in mouse, CCL19, CCL21Ser, and CCL21Leu, divide their roles in immune organs is unclear. By producing mice specifically deficient in CCL21Ser, we show that CCL21Ser is essential for the accumulation of positively selected thymocytes in the thymic medulla. CCL21Ser-deficient mice were impaired in the medullary deletion of self-reactive thymocytes and developed autoimmune dacryoadenitis. T cell accumulation in the lymph nodes was also defective. These results indicate a nonredundant role of CCL21Ser in the establishment of selftolerance in T cells in the thymic medulla, and reveal a functional inequality among CCR7 ligands in vivo.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Rockefeller University Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2017 Kozai et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org /terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial– Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/)","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15409538","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"00221007","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12119243","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA00697559","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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