{"created":"2024-10-25T10:16:22.361390+00:00","id":2003381,"links":{},"metadata":{"_buckets":{"deposit":"62f07f62-c414-490b-aa64-a53ff44faede"},"_deposit":{"created_by":7,"id":"2003381","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003381"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003381","sets":["1713829974766:1713854682253:1716422253187:1716423640748","1713853213384:1713853295607"]},"author_link":["223","1573","1586","865"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-08-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"115","bibliographicPageStart":"111","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"四国医学雑誌","bibliographic_titleLang":"ja"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Obesity is a major cause of insulin resistance and is considered a chronic low-grade inflammatory disease. Substantial evidence has accumulated in recent years that chronic infiltration and activation of macrophages in white adipose tissue underlie the obesity-related component of these insulin resistant states. In the present study, we examined the role of Cbl-b, ubiquitin ligase, in insulin action. Elderly Cbl-b-deficient mice（Cbl-b－/－mice）developed glucose intolerance and peripheral insulin resistance. Deficiency of Cbl-b gene was associated with infiltration of macrophages into the WAT and expression of cytokines, such as tumor necrosis factor-α, interleukin-6 and monocyte chemoattractant protein-1. Furthermore, Vav1, a key factor in macrophage activation, was highly phosphorylated in peritoneal Cbl-b－/－macrophages, compared with wild type macrophages, suggesting that Cbl-b deficiency induces macrophage activation. Our results suggest that Cbl-b is a negative regulator of macrophage activation, and that macrophage activation by Cbl-b deficiency, at least in part, contributes to the peripheral insulin resistance and glucose intolerance.  ","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"徳島医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00373699","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN00102041","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"249749"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"平坂, 勝也","creatorNameLang":"ja"},{"creatorName":"ヒラサカ, カツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirasaka, Katsuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"平坂","familyNameLang":"ja"},{"familyName":"ヒラサカ","familyNameLang":"ja-Kana"},{"familyName":"Hirasaka","familyNameLang":"en"}],"givenNames":[{"givenName":"勝也","givenNameLang":"ja"},{"givenName":"カツヤ","givenNameLang":"ja-Kana"},{"givenName":"Katsuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"223","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70432747","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70432747"}]},{"creatorNames":[{"creatorName":"河野, 尚平","creatorNameLang":"ja"},{"creatorName":"コウノ, ショウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kohno, Shohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"加川, 祥子","creatorNameLang":"ja"},{"creatorName":"カガワ, サチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kagawa, Sachiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中尾, 玲子","creatorNameLang":"ja"},{"creatorName":"ナカオ, レイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakao, Reiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"中尾","familyNameLang":"ja"},{"familyName":"ナカオ","familyNameLang":"ja-Kana"},{"familyName":"Nakao","familyNameLang":"en"}],"givenNames":[{"givenName":"玲子","givenNameLang":"ja"},{"givenName":"レイコ","givenNameLang":"ja-Kana"},{"givenName":"Reiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"865","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"323762/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/323762/profile-ja.html"},{"nameIdentifier":"20582696","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20582696"}]},{"creatorNames":[{"creatorName":"不老地, 治美","creatorNameLang":"ja"},{"creatorName":"フロウチ, ハルミ","creatorNameLang":"ja-Kana"},{"creatorName":"Furochi, Harumi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"岸, 恭一","creatorNameLang":"ja"},{"creatorName":"キシ, キョウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Kishi, Kyoichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"岸","familyNameLang":"ja"},{"familyName":"キシ","familyNameLang":"ja-Kana"},{"familyName":"Kishi","familyNameLang":"en"}],"givenNames":[{"givenName":"恭一","givenNameLang":"ja"},{"givenName":"キョウイチ","givenNameLang":"ja-Kana"},{"givenName":"Kyoichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1573","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60126/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60126/profile-ja.html"},{"nameIdentifier":"80035435","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80035435"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"二川, 健","creatorNameLang":"ja"},{"creatorName":"ニカワ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nikawa, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"二川","familyNameLang":"ja"},{"familyName":"ニカワ","familyNameLang":"ja-Kana"},{"familyName":"Nikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"健","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1586","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60150/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60150/profile-ja.html"},{"nameIdentifier":"20263824","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20263824"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-07-11"}],"displaytype":"detail","filename":"LID201707104002.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003381/files/LID201707104002.pdf"},"version_id":"14a49f2c-dc09-4050-9d61-7152e60227bb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cbl-b-deficient mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"white adipose tissue","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cbl-b欠損によるマクロファージの活性化を介した耐糖能異常","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cbl-b欠損によるマクロファージの活性化を介した耐糖能異常","subitem_title_language":"ja"},{"subitem_title":"Cbl-b ケッソン ニ ヨル マクロファージ ノ カッセイカ オ カイシタ タイトウノウ イジョウ","subitem_title_language":"ja-Kana"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716423640748"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-07-12"},"publish_date":"2017-07-12","publish_status":"0","recid":"2003381","relation_version_is_last":true,"title":["Cbl-b欠損によるマクロファージの活性化を介した耐糖能異常"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T12:39:22.217999+00:00"}