{"created":"2024-10-28T02:30:37.381418+00:00","id":2003867,"links":{},"metadata":{"_buckets":{"deposit":"18aa3fad-d03a-4dd7-8d30-242a03fc10a9"},"_deposit":{"created_by":7,"id":"2003867","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003867"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003867","sets":["1713829974766:1713854681789:1716364521649:1716421736581","1713853213384:1713853295607"]},"author_link":["1591","1548"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"217","bibliographicPageStart":"215","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hepatitis B virus (HBV) infection has been implicated in the development of hepatocellular and hematopoietic malignancies. We describe a patient with chronic hepatitis B who developed hepatosplenic γδT-cell lymphoma. A 45-year-old woman presented with marked hepatosplenomegaly and hepatic failure during the course of chronic hepatitis B. Peripheral blood examination revealed57% abnormal lymphoid cells which expressed the γδT-cell receptor. The cytogenetic analysis of tumor cells showed an abnormal karyotype  47, XX, -13, +2mar in all 20 metaphases examined. A clonal rearrangement of the T-cell receptor genes was demonstrated by Southern blot analysis, showing monoclonal expansion of tumor cells. A liver biopsy specimen showed fibrosis of the portal areas and sinusoidal infiltration of tumor cells. HBV infection was documented by the presence of IgG anti-HBc and anti-HBs antibodies in serum. Although HBV-DNA was not detected in tumor cells by polymerase chain reaction analysis, there is a possibility that proliferation of γδT cells in response to HBV infection played a role in the pathogenesis of hepatosplenic γδT-cell lymphoma.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Toshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ワカツキ, シンゴ","creatorNameLang":"ja"},{"creatorName":"ワカツキ, シンゴ","creatorNameLang":"ja-Kana"},{"creatorName":"Wakatsuki, Shingo","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"上原, 久典","creatorNameLang":"ja"},{"creatorName":"ウエハラ, ヒサノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Uehara, Hisanori","creatorNameLang":"en"}],"familyNames":[{"familyName":"上原","familyNameLang":"ja"},{"familyName":"ウエハラ","familyNameLang":"ja-Kana"},{"familyName":"Uehara","familyNameLang":"en"}],"givenNames":[{"givenName":"久典","givenNameLang":"ja"},{"givenName":"ヒサノリ","givenNameLang":"ja-Kana"},{"givenName":"Hisanori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1548","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60072/profile-ja.html","nameIdentifierScheme":"徳島大学 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Toshio","creatorNameLang":"en"}],"familyNames":[{"familyName":"松本","familyNameLang":"ja"},{"familyName":"マツモト","familyNameLang":"ja-Kana"},{"familyName":"Matsumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"俊夫","givenNameLang":"ja"},{"givenName":"トシオ","givenNameLang":"ja-Kana"},{"givenName":"Toshio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1591","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60162/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60162/profile-ja.html"},{"nameIdentifier":"20157374","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20157374"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-11-16"}],"displaytype":"detail","filename":"jmi_44_3-4_215.pdf","filesize":[{"value":"124 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003867/files/jmi_44_3-4_215.pdf"},"version_id":"d503163e-54a9-4662-8825-5f6eab084129"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hepatosplenic lymphoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"γδT-cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatitis B virus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic hepatitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatosplenomegaly","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hepatosplenic γδT-cell lymphoma associated with hepatitis B virus infection","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hepatosplenic γδT-cell lymphoma associated with hepatitis B virus infection","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716421736581"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-11-16"},"publish_date":"2017-11-16","publish_status":"0","recid":"2003867","relation_version_is_last":true,"title":["Hepatosplenic γδT-cell lymphoma associated with hepatitis B virus infection"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T08:31:52.041135+00:00"}