{"created":"2024-10-28T02:30:46.170628+00:00","id":2003869,"links":{},"metadata":{"_buckets":{"deposit":"56ef0c75-791f-48e5-ad81-db56e2dde6ab"},"_deposit":{"created_by":7,"id":"2003869","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003869"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003869","sets":["1713853213384:1713853295607"]},"author_link":["173"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The pathogenesis of influenza encephalopathy or encephalitis is poorly understood. This review summarizes our recent studies of the roles played by inflammatory cytokines, inducible nitric oxide synthase (iNOS), adhesion molecules and mini-plasmin in influenza encephalitis. After the intranasal infection of newborn mice with the non-neurotropic strain of influenza A virus (IAV) Aichi/2/68/H3N2, encephalitis and severe brain edema were observed within 3-5 days. IAV-RNA and abnormalities in the blood-brain barrier permeability were detected in association with an increase in them RNA expressions of endothelin-1, iNOS, and tumor necrosis factor-α. Furthermore, the accumulation in the brain capillaries of mini-plasmin, which proteolytically induces the viral envelope fusion activity and allows the virus to enter the cells, changes the brain from non-susceptible to susceptible to non-neurotropic IAV multiplication. The accumulation of mini-plasmin was markedly greater in newborn mice with an impaired mitochondrial fatty acid metabolism. These inflammatory mediators and the accumulation of mini-plasmin in the brain may play an important role in the onset and progression of IAV encephalitis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"154897"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yao, Dengfu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"桒島, 正道","creatorNameLang":"ja"},{"creatorName":"クワジマ, マサミチ","creatorNameLang":"ja-Kana"},{"creatorName":"Kuwajima, Masamichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"木戸, 博","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"173","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-11-22"}],"displaytype":"detail","filename":"jmi_50_1-2_1.pdf","filesize":[{"value":"205 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003869/files/jmi_50_1-2_1.pdf"},"version_id":"bb2a8b6d-ab60-4566-8177-ae84b5d0f74f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"influenza encephalitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nitric oxide synthase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mini-plasmin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pathologic mechanisms of influenza encephalitis with an abnormal expression of inflammatory cytokines and accumulation of mini-plasmin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pathologic mechanisms of influenza encephalitis with an abnormal expression of inflammatory cytokines and accumulation of mini-plasmin","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-11-22"},"publish_date":"2017-11-22","publish_status":"0","recid":"2003869","relation_version_is_last":true,"title":["Pathologic mechanisms of influenza encephalitis with an abnormal expression of inflammatory cytokines and accumulation of mini-plasmin"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T02:30:54.540384+00:00"}