{"created":"2024-10-28T02:37:18.997085+00:00","id":2003954,"links":{},"metadata":{"_buckets":{"deposit":"63c7d577-f629-4d57-b1b3-fcd1c0f84f83"},"_deposit":{"created_by":7,"id":"2003954","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003954"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003954","sets":["1713829974766:1713854681789:1716364518976:1716421365170","1713853213384:1713853295607"]},"author_link":["661","1608"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"64","bibliographicPageStart":"57","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study was conducted to address the question of whether the β3-adrenergic receptor gene mutation (Trp 64 Arg) is associated with metabolic disease in Japanese patients with schizophrenia. Methods : In a cross-sectional study, 89 participants were grouped into three genotypes. The 64 Arg allelic frequency in patients with or without metabolic disease was analyzed. Anthropometrics variables and biochemical parameters were compared among the genotypes. Results : The 64 Arg allele, which had a frequency of 0.22, was not associated with obesity, type 2 diabetes mellitus, dyslipidemias, or hypertension. No significant differences among the genotypes were found in current age, age at diagnosis with schizophrenia, body mass index, waist-hip ratio, plasma glucose, plasma insulin, triglycerides, free fatty acids. Patients with the 64 Arg allele had greater 24-h excretion of norepinephrine than those lacking the variant (p=0.019). Conclusion : The 64Arg allelic mutation is not associated with obesity, type 2 diabetes mellitus, lipid metabolism dysfunction, or hypertension in Japanese patients with schizophrenia.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.52.57"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.52.57","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"132590"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ナガノ, タカマサ","creatorNameLang":"ja"},{"creatorName":"ナガノ, タカマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagano, Takamasa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツダ, ユキヒコ","creatorNameLang":"ja"},{"creatorName":"マツダ, ユキヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuda, Yukihiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"谷岡, 哲也","creatorNameLang":"ja"},{"creatorName":"タニオカ, テツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanioka, Tetsuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"谷岡","familyNameLang":"ja"},{"familyName":"タニオカ","familyNameLang":"ja-Kana"},{"familyName":"Tanioka","familyNameLang":"en"}],"givenNames":[{"givenName":"哲也","givenNameLang":"ja"},{"givenName":"テツヤ","givenNameLang":"ja-Kana"},{"givenName":"Tetsuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1608","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60191/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60191/profile-ja.html"},{"nameIdentifier":"90319997","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90319997"}]},{"creatorNames":[{"creatorName":"ヨシオカ, タカオキ","creatorNameLang":"ja"},{"creatorName":"ヨシオカ, タカオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshioka, Takaoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒロイ, タダシ","creatorNameLang":"ja"},{"creatorName":"ヒロイ, タダシ","creatorNameLang":"ja-Kana"},{"creatorName":"Hiroi, Tadashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨシカワ, ケンイチ","creatorNameLang":"ja"},{"creatorName":"ヨシカワ, ケンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshikawa, Kenichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカベ, ケンイチロウ","creatorNameLang":"ja"},{"creatorName":"オカベ, ケンイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Okabe, Ken-ichiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"大坂, 京子","creatorNameLang":"ja"},{"creatorName":"オオサカ, キョウコ","creatorNameLang":"ja-Kana"},{"creatorName":"Osaka, Kyoko","creatorNameLang":"en"}],"familyNames":[{"familyName":"大坂","familyNameLang":"ja"},{"familyName":"オオサカ","familyNameLang":"ja-Kana"},{"familyName":"Osaka","familyNameLang":"en"}],"givenNames":[{"givenName":"京子","givenNameLang":"ja"},{"givenName":"キョウコ","givenNameLang":"ja-Kana"},{"givenName":"Kyoko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"661","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30553490","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30553490"}]},{"creatorNames":[{"creatorName":"ナガミネ, イサオ","creatorNameLang":"ja"},{"creatorName":"ナガミネ, イサオ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagamine, Isao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカサカ, ヨウイチロウ","creatorNameLang":"ja"},{"creatorName":"タカサカ, ヨウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Takasaka, Yoichiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-01-23"}],"displaytype":"detail","filename":"jmi_52_1-2_57.pdf","filesize":[{"value":"74.6 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003954/files/jmi_52_1-2_57.pdf"},"version_id":"a4fb562f-98fc-41eb-ac63-acec2dc87c08"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"schizophrenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β 3-adrenergic receptor polymorphism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"obesity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metabolic disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Trp 64 Arg allele","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"No association of the Trp 64 Arg mutation of the β3-adrenergic receptor gene with obesity, type 2 diabetes mellitus, hyperlipidemia, and hypertension in Japanese patients with schizophrenia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"No association of the Trp 64 Arg mutation of the β3-adrenergic receptor gene with obesity, type 2 diabetes mellitus, hyperlipidemia, and hypertension in Japanese patients with schizophrenia","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716421365170"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-23"},"publish_date":"2018-01-23","publish_status":"0","recid":"2003954","relation_version_is_last":true,"title":["No association of the Trp 64 Arg mutation of the β3-adrenergic receptor gene with obesity, type 2 diabetes mellitus, hyperlipidemia, and hypertension in Japanese patients with schizophrenia"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T01:44:27.442441+00:00"}