{"created":"2024-10-28T02:37:38.147225+00:00","id":2003958,"links":{},"metadata":{"_buckets":{"deposit":"d2ec67b1-494d-4ebd-844b-eb6971144c68"},"_deposit":{"created_by":7,"id":"2003958","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003958"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003958","sets":["1713853213384:1713853295607"]},"author_link":["1542","229","10","1550","1531"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"92","bibliographicPageStart":"85","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Macrophage-derived chemokine (MDC/CCL22) and thymus-and activation-regulated chemokine (TARC/CCL17) are ligands for CC chemokine receptor 4. Recently, TARC has been reported to play a role in the pathogenesis of idiopathic eosinophilic pneumonia (IEP). The purpose of this study was to evaluate the role of MDC in IEP and other interstitial lung diseases (ILDs). MDC and TARC in the bronchoalveolar lavage fluid (BALF) were measured by enzymelinked immunosorbent assay in patients with ILDs and healthy volunteers (HV). We also examined the expression of MDC mRNA in alveolar macrophages (AM) by real-time quantitative reverse transcriptase-polymerase chain reaction. Both MDC and TARC were detected only in BALF obtained from IEP patients. The concentration of MDC was higher than that of TARC in all cases. The level of MDC in IEP correlated with that of TARC. AM from IEP patients expressed a significantly higher amount of MDC than that from HV at the levels of protein and mRNA. MDC in BALF from IEP dramatically decreased when patients achieved remission. These findings suggest that MDC, in addition to TARC, might be involved in the pathogenesis of IEP, and AM play a role in the elevation of MDC in IEP.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.52.85"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.52.85","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"136629"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"マナベ, カズヨシ","creatorNameLang":"ja"},{"creatorName":"マナベ, カズヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Manabe, Kazuyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"西岡, 安彦","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岸, 潤","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"229","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イナヤマ, マミ","creatorNameLang":"ja"},{"creatorName":"イナヤマ, マミ","creatorNameLang":"ja-Kana"},{"creatorName":"Inayama, Mami","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"青野, 純典","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"10","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ナカムラ, ヨウイチ","creatorNameLang":"ja"},{"creatorName":"ナカムラ, ヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Yoichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオグシ, フミタカ","creatorNameLang":"ja"},{"creatorName":"オオグシ, フミタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Ogushi, Fumitaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"バンドウ, ヒロヤス","creatorNameLang":"ja"},{"creatorName":"バンドウ, ヒロヤス","creatorNameLang":"ja-Kana"},{"creatorName":"Bando, Hiroyasu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"谷, 憲治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"曽根, 三郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1531","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-01-18"}],"displaytype":"detail","filename":"jmi_52_1-2_85.pdf","filesize":[{"value":"202 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003958/files/jmi_52_1-2_85.pdf"},"version_id":"9b13ec28-f644-4028-9a50-05e20d00686f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bronchoalveolar lavage fluid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage-derived chemokine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thymus-and activation-regulated chemokine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"eosinophilic pneumonia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alveolar macrophages","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interstitial lung diseases","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Elevation of macrophage-derived chemokine in eosinophilic pneumonia : a role of alveolar macrophages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Elevation of macrophage-derived chemokine in eosinophilic pneumonia : a role of alveolar macrophages","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-18"},"publish_date":"2018-01-18","publish_status":"0","recid":"2003958","relation_version_is_last":true,"title":["Elevation of macrophage-derived chemokine in eosinophilic pneumonia : a role of alveolar macrophages"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T02:37:46.715912+00:00"}