{"created":"2024-10-28T02:37:42.434696+00:00","id":2003959,"links":{},"metadata":{"_buckets":{"deposit":"18b8a628-3a0b-4c26-9eac-e4694d5010ab"},"_deposit":{"created_by":7,"id":"2003959","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003959"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003959","sets":["1713853213384:1713853295607"]},"author_link":["1550","1531"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"100","bibliographicPageStart":"93","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To determine the significance of proteases in interstitial lung diseases, we examined the activity of cathepsins, thrombin, and aminopeptidase in bronchoalveolar lavage (BAL) fluid from patients with these disorders. Significantly increased activities of cathepsin H and aminopeptidase were detected in BAL fluid from patients with idiopathic pulmonary fibrosis (IPF), cryptogenic organizing pneumonia (COP), chronic eosinophilic pneumonia (CEP) and hypersensitivity pneumonitis (HP). Significantly higher activity of cathepsin B was found in BAL fluid from patients with CEP. The activity of thrombin was significantly higher in patients with IPF and CEP. In patients with IPF, there were significant correlations between neutrophil number and the activity of cathepsin B, cathepsin H or aminopeptidase. In patients with COP and HP, the activity of the proteases was significantly higher in patients with higher number of lymphocytes than in those with lower number of lymphocytes. The present study suggests that the activity of the proteases is a useful marker in activity of the interstitial lung diseases, and may have a role in the pathogenesis of these disorders.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.52.93"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.52.93","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"136618"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"キムラ, マコト","creatorNameLang":"ja"},{"creatorName":"キムラ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Kimura, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"谷, 憲治","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ミヤタ, ジュンヤ","creatorNameLang":"ja"},{"creatorName":"ミヤタ, ジュンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyata, Junya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サトウ, ケイコ","creatorNameLang":"ja"},{"creatorName":"サトウ, ケイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Keiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハヤシ, アキヒト","creatorNameLang":"ja"},{"creatorName":"ハヤシ, アキヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Akihito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオツカ, シンサク","creatorNameLang":"ja"},{"creatorName":"オオツカ, シンサク","creatorNameLang":"ja-Kana"},{"creatorName":"Otsuka, Shinsaku","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"浦田, 知之","creatorNameLang":"ja"},{"creatorName":"ウラタ, トモユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Urata, Tomoyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"曽根, 三郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1531","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-01-18"}],"displaytype":"detail","filename":"jmi_52_1-2_93.pdf","filesize":[{"value":"853 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003959/files/jmi_52_1-2_93.pdf"},"version_id":"75f3e5b4-2386-4cec-9169-8b20cc65bdc7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"interstitial lung diseases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cathepsin H","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cathepsin B","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cathepsin G","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thrombin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aminopeptidase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-18"},"publish_date":"2018-01-18","publish_status":"0","recid":"2003959","relation_version_is_last":true,"title":["The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T02:37:51.782673+00:00"}