{"created":"2024-10-28T02:38:10.178294+00:00","id":2003965,"links":{},"metadata":{"_buckets":{"deposit":"695bbd4e-da1a-45ed-98ff-d487e5629809"},"_deposit":{"created_by":7,"id":"2003965","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2003965"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02003965","sets":["1713829974766:1713854681789:1716364518976:1716421364877","1713853213384:1713853295607"]},"author_link":["1658"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"136","bibliographicPageStart":"127","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adenylate kinase (hereinafter referred to as AK) catalyzes a reversible high-energy phosphoryl transfer reaction between adenine nucleotides. The enzyme contributes to the homeostasis of cellular adenine nucleotide composition in addition to the nucleotide biosynthesis. So far, six AK isozymes, AK1, AK2, AK3, AK4, AK5, andAK6, were identified.AK1 is localized in neuronal processes, sperm tail and on the cytoskeleton in cardiac cells at high concentrations, suggesting its regulatory function as a high-energyβ-phosphoryl transfer chain from ATP-synthesizing sites to the ATP-utilizing sites in the cell. AK2, AK3 and AK4 are mitochondrial proteins. AK2 is expressed in the intermembrane space, while AK3 and AK4 are localized in the mitochondrial matrix. AK3 is expressed in all tissues except for red blood cells indicating thatAK3 gene is a housekeeping-type gene. On the other hand, AK4is tissue specifically expressed mainly in kidney, brain, heart, and liver although its enzymatic activity is not yet detected. AK5 is solely expressed in a limited area of brain. AK6 is recently identified in nucleus, suggesting its role in nuclear nucleotide metabolism. All data, so far reported, indicated the function of AK is associated with the mechanism of efficient transfer of high-energy phosphate in micro-compartment within the cell.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.52.127"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.52.127","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"135674"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"野間, 隆文","creatorNameLang":"ja"},{"creatorName":"ノマ, タカフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Noma, Takafumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"野間","familyNameLang":"ja"},{"familyName":"ノマ","familyNameLang":"ja-Kana"},{"familyName":"Noma","familyNameLang":"en"}],"givenNames":[{"givenName":"隆文","givenNameLang":"ja"},{"givenName":"タカフミ","givenNameLang":"ja-Kana"},{"givenName":"Takafumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1658","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60320/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60320/profile-ja.html"},{"nameIdentifier":"40189428","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40189428"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-01-18"}],"displaytype":"detail","filename":"jmi_52_3-4_127.pdf","filesize":[{"value":"430 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2003965/files/jmi_52_3-4_127.pdf"},"version_id":"712a63fb-e9c3-42d6-b54c-a5d147249505"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adenine nucleotide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adenylate kinase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"high-energy phosphoryl transfer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"homeostasis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"isozyme","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dynamics of nucleotide metabolism as a supporter of life phenomena","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dynamics of nucleotide metabolism as a supporter of life phenomena","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716421364877"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-18"},"publish_date":"2018-01-18","publish_status":"0","recid":"2003965","relation_version_is_last":true,"title":["Dynamics of nucleotide metabolism as a supporter of life phenomena"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T03:01:46.448795+00:00"}