{"created":"2024-10-28T02:42:25.138746+00:00","id":2004019,"links":{},"metadata":{"_buckets":{"deposit":"bc853cfc-ef4f-4f84-b4d6-48c2b98fcc20"},"_deposit":{"created_by":7,"id":"2004019","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004019"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004019","sets":["1713829974766:1713854681789:1716364518663:1716421309759","1713853213384:1713853295607"]},"author_link":["1594","1604"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"276","bibliographicPageStart":"271","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have previously shown that human immunodeficiency virus type 2 (HIV-2) without functional vpx and vpr genes is severely defective for viral growth in lymphocytic cells, and suggested that the virions produced in the absence of Vpx and Vpr are critically damaged. To examine the nature of replication-defect for the vpx/vpr double mutant, we quantitatively and morphologically studied the virions produced in cells transfected or infected with wild type clone, single (vpx and vpr mutants) or the double mutant. While no significant difference in virion production was found for various virus clones in transfected cells, a major growth retardation in infected cells was readily observed for the vpx and vpx/vpr mutants. In particular, no viral growth was detected for the double mutant. By contrast to the very distinct growth characteristics of the three mutant clones, no appreciable difference in virion morphology was noted. These results indicated that Vpx and Vpr of HIV-2 may cooperatively contribute to virion infectivity without affecting virion morphogenesis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Akio","creatorNameLang":"en"}],"familyNames":[{"familyName":"足立","familyNameLang":"ja"},{"familyName":"アダチ","familyNameLang":"ja-Kana"},{"familyName":"Adachi","familyNameLang":"en"}],"givenNames":[{"givenName":"昭夫","givenNameLang":"ja"},{"givenName":"アキオ","givenNameLang":"ja-Kana"},{"givenName":"Akio","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1594","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60165/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60165/profile-ja.html"},{"nameIdentifier":"90127043","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90127043"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"内山, 恒夫","creatorNameLang":"ja"},{"creatorName":"ウチヤマ, ツネオ","creatorNameLang":"ja-Kana"},{"creatorName":"Uchiyama, Tsuneo","creatorNameLang":"en"}],"familyNames":[{"familyName":"内山","familyNameLang":"ja"},{"familyName":"ウチヤマ","familyNameLang":"ja-Kana"},{"familyName":"Uchiyama","familyNameLang":"en"}],"givenNames":[{"givenName":"恒夫","givenNameLang":"ja"},{"givenName":"ツネオ","givenNameLang":"ja-Kana"},{"givenName":"Tsuneo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1604","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90151901","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90151901"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-12-07"}],"displaytype":"detail","filename":"jmi_53_3-4_271.pdf","filesize":[{"value":"480 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004019/files/jmi_53_3-4_271.pdf"},"version_id":"92976b36-ec72-4ed7-9fd6-ec1127db60f0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HIV-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"accessory proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Vpx","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Vpr","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Morphological study on biologically distinct vpx/vpr mutants of HIV-2","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Morphological study on biologically distinct vpx/vpr mutants of HIV-2","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716421309759"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-12-07"},"publish_date":"2017-12-07","publish_status":"0","recid":"2004019","relation_version_is_last":true,"title":["Morphological study on biologically distinct vpx/vpr mutants of HIV-2"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T01:41:55.064790+00:00"}