{"created":"2024-10-28T02:43:42.033328+00:00","id":2004036,"links":{},"metadata":{"_buckets":{"deposit":"5a53b92a-87ab-4a0a-a765-34ad81400840"},"_deposit":{"created_by":7,"id":"2004036","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004036"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004036","sets":["1713829974766:1713854681789:1716364518018:1716365772163","1713853213384:1713853295607"]},"author_link":["176","1559"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"60","bibliographicPageStart":"54","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Capecitabine monotherapy was administered for 25 patients with advanced or recurrent breast cancer, and the clinical therapeutic efficacy and its relationship to expression of 5-fluorouracil-related enzymes (i.e., thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD)) were investigated. The expressions of TP, TS and DPD were determined by immunohistochemical staining techniques and rated using a scoring system of 1～4. The expression score for TP/DPD showed a statistically significant correlation with the clinical response, whereas the expression score for TP/TS also showed a correlation but it was not statistically significant. The number of patients was small, but the results revealed the potential of application of the TP/DPD expression score as a factor for predicting the efficacy of the drug in individual patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.55.54"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.55.54","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"192649"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ホンダ, ジュンコ","creatorNameLang":"ja"},{"creatorName":"ホンダ, ジュンコ","creatorNameLang":"ja-Kana"},{"creatorName":"Honda, Junko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ササ, ミツノリ","creatorNameLang":"ja"},{"creatorName":"ササ, ミツノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasa, Mitsunori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリヤ, タクヤ","creatorNameLang":"ja"},{"creatorName":"モリヤ, タクヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Moriya, Takuya","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"坂東, 良美","creatorNameLang":"ja"},{"creatorName":"バンドウ, ヨシミ","creatorNameLang":"ja-Kana"},{"creatorName":"Bando, Yoshimi","creatorNameLang":"en"}],"familyNames":[{"familyName":"坂東","familyNameLang":"ja"},{"familyName":"バンドウ","familyNameLang":"ja-Kana"},{"familyName":"Bando","familyNameLang":"en"}],"givenNames":[{"givenName":"良美","givenNameLang":"ja"},{"givenName":"ヨシミ","givenNameLang":"ja-Kana"},{"givenName":"Yoshimi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1559","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60096/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60096/profile-ja.html"},{"nameIdentifier":"00238239","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00238239"}]},{"creatorNames":[{"creatorName":"ヒロセ, トシユキ","creatorNameLang":"ja"},{"creatorName":"ヒロセ, トシユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirose, Toshiyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカハシ, マサコ","creatorNameLang":"ja"},{"creatorName":"タカハシ, マサコ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Masako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"長尾, 妙子","creatorNameLang":"ja"},{"creatorName":"ナガオ, タエコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagao, Taeko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"丹黒, 章","creatorNameLang":"ja"},{"creatorName":"タンゴク, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Tangoku, Akira","creatorNameLang":"en"}],"familyNames":[{"familyName":"丹黒","familyNameLang":"ja"},{"familyName":"タンゴク","familyNameLang":"ja-Kana"},{"familyName":"Tangoku","familyNameLang":"en"}],"givenNames":[{"givenName":"章","givenNameLang":"ja"},{"givenName":"アキラ","givenNameLang":"ja-Kana"},{"givenName":"Akira","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"176","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"113573/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/113573/profile-ja.html"},{"nameIdentifier":"10197593","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10197593"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-01-18"}],"displaytype":"detail","filename":"jmi_55_1-2_54.pdf","filesize":[{"value":"545 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004036/files/jmi_55_1-2_54.pdf"},"version_id":"38eabe0c-296c-4409-9e24-63765b7a7574"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"breast cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"capecitabine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dihydropyrimidine dehydrogenase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"predictive factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thymidine phosphorylase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancerpreliminary results","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancerpreliminary results","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716365772163"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-18"},"publish_date":"2018-01-18","publish_status":"0","recid":"2004036","relation_version_is_last":true,"title":["Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancerpreliminary results"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:33:04.594784+00:00"}