{"created":"2024-10-28T02:46:32.861778+00:00","id":2004073,"links":{},"metadata":{"_buckets":{"deposit":"90a6deb8-456e-4d18-8299-87979101efca"},"_deposit":{"created_by":7,"id":"2004073","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004073"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004073","sets":["1713829974766:1713854681789:1716364517711:1716365817817","1713853213384:1713853295607"]},"author_link":["287"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"The journal of medical investigation : JMI","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Colorectal cancer is a leading cause of cancer-related mortality worldwide. Therefore, an appropriate prevention strategy should be urgently established. Chemoprevention involves the use of oral agents to suppress the development of cancer. Recent progress in the molecular analysis of colorectal cancer has revealed many candidate molecules for chemoprevention. Many new agents targeting these molecules have also been developed. These agents are largely classified into three categories : 1) Signal transduction modulators including epidermal growth factor (EGF) receptor inhibitors, anti-vascular endothelial growth factor (VEGF) antibodies, and inhibitors of oncogene products. 2) Epigenetic modulators including peroxisome proliferative activated receptor (PPAR)-γ agonists, estrogen receptor (ER)-β , and histone deacetylase inhibitors. 3) Anti-inflammatory modulators including cyclooxygenase (COX)-2, EP 1-4, and NF-kB. Of these agents, some actually proceeded to human clinical trials, and have been shown to be active chemopreventive agents.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"195394"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"高山, 哲治","creatorNameLang":"ja"},{"creatorName":"タカヤマ, テツジ","creatorNameLang":"ja-Kana"},{"creatorName":"Takayama, Tetsuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"高山","familyNameLang":"ja"},{"familyName":"タカヤマ","familyNameLang":"ja-Kana"},{"familyName":"Takayama","familyNameLang":"en"}],"givenNames":[{"givenName":"哲治","givenNameLang":"ja"},{"givenName":"テツジ","givenNameLang":"ja-Kana"},{"givenName":"Tetsuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"287","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"169695/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/169695/profile-ja.html"},{"nameIdentifier":"10284994","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10284994"}]},{"creatorNames":[{"creatorName":"郷司, 敬洋","creatorNameLang":"ja"},{"creatorName":"ゴウジ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Goji, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"谷口, 達哉","creatorNameLang":"ja"},{"creatorName":"タニグチ, タツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Taniguchi, Tatsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イノウエ, アツシ","creatorNameLang":"ja"},{"creatorName":"イノウエ, アツシ","creatorNameLang":"ja-Kana"},{"creatorName":"Inoue, Atsushi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2017-11-28"}],"displaytype":"detail","filename":"jmi_56_1-2_1.pdf","filesize":[{"value":"526 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004073/files/jmi_56_1-2_1.pdf"},"version_id":"6d0dc1ad-c551-4f4a-9069-1d3c62acd697"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"colorectal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chemoprevention","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aberrant crypt foci","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Chemoprevention of colorectal cancer : experimental and clinical aspects","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Chemoprevention of colorectal cancer : experimental and clinical aspects","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716365817817"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-11-28"},"publish_date":"2017-11-28","publish_status":"0","recid":"2004073","relation_version_is_last":true,"title":["Chemoprevention of colorectal cancer : experimental and clinical aspects"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T06:43:22.718383+00:00"}