| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2017-11-22 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1016/j.etap.2016.09.024 |
| 出版タイプ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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タイトル |
Chlorhexidine possesses unique cytotoxic actions in rat thymic lymphocytes : Its relation with electrochemical property of membranes |
| 著者 |
ノナミ, カヨ
サイトウ, ショウヘイ
ニシムラ ダンジョウバラ, ユミコ
| ja |
ニシムラ ダンジョウバラ, ユミコ
|
| ja-Kana |
ニシムラ ダンジョウバラ, ユミコ
|
| en |
Nishimura-Danjyobara, Yumiko
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Search repository
イシダ, シロウ
小山, 保夫
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| 抄録 |
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内容記述 |
Chlorhexidine (CHX) is an antibacterial agent used in various types of pharmaceutical products. Therefore, CHX is easily found around us. Owing to its positive charge, the electrochemical property of cell membranes was assumed to be a key point of cytotoxic action of CHX. Depolarization of membranes attenuated the cytotoxic action of CHX in rat thymic lymphocytes. CHX interfered with annexin V binding to membranes. Manipulations to induce exposure of phosphatidylserine on the outer membrane surface augmented the cytotoxic action of CHX, indicating that changes in the electrochemical property of membranes affected the cytotoxic action of CHX. Hence, CHX might kill cells physiologically undergoing apoptosis, resulting instead in necrotic cell death. However, the threshold CHX concentration in this in vitro study was slightly higher than blood CHX concentrations observed clinically. Therefore, these results may support the safety of CHX use although CHX possesses unique cytotoxic actions described in this study. |
| キーワード |
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主題 |
Chlorhexidine |
| キーワード |
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|
主題 |
Hydrogen peroxide |
| キーワード |
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|
主題 |
Cytotoxicity |
| キーワード |
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|
主題 |
Lymphocytes |
| キーワード |
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主題 |
Phosphatidylserine |
| 書誌情報 |
en : Environmental Toxicology and Pharmacology
巻 48,
p. 17-21,
発行日 2016-10-01
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13826689 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1107880X |
| 出版者 |
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出版者 |
Elsevier |
| 権利情報 |
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|
権利情報 |
© 2016 Elsevier B.V. All rights reserved.
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
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|
識別子 |
320742 |
| 言語 |
|
|
言語 |
eng |
etap_48_17.pdf (1.11 MB)
