{"created":"2024-10-28T02:57:17.520846+00:00","id":2004199,"links":{},"metadata":{"_buckets":{"deposit":"c355e91a-0cfc-4e77-b2f2-4306867c6641"},"_deposit":{"created_by":7,"id":"2004199","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004199"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004199","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["1583","761","1578","1585"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"年齢に応じた血中活性型ビタミンD濃度, 腎Cyp27b1およびCyp24a1発現に対する食餌性リン反応性の変化には腎α-Klotho遺伝子発現が関連する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"74","bibliographicPageStart":"68","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, we investigated the relationship between age-related changes in renal α-Klotho gene expression, vitamin D metabolism and the responsiveness of dietary phosphate in 1, 2 and 13 month-old mice fed a high phosphate (phosphate 1.2%) diet or low phosphate (phosphate 0.02%) diet for 5 days. We found that 1,25-dihydroxyvitamin D levels in plasma were significantly lower in the high phosphate group than the low phosphate group for 1 and 2 month-old mice, but not 13 month-old mice. In addition, in the high phosphate group plasma 1,25-dihydroxyvitamin D levels were decreased in 2 month-old mice relative to 1 month-old mice, but 13 month-old mice had higher levels than 2 month-old mice. In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group. Interestingly, renal α-Klotho mRNA and protein levels were significant change with age. Furthermore, α-Klotho mRNA expression showed a significant negative correlation with plasma 1,25-dihydroxyvitamin D levels in the high phosphate group. Our results suggest that age-related alterations in renal α-Klotho expression could affect the responsiveness of dietary phosphate to vitamin D metabolism.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"SOCIETY FOR FREE RADICAL RESEARCH JAPAN","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2018 Society for Free Radical Research Japan","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"18805086","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"09120009","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10710201","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12091064","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3119号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-10-26"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は, 著者Ryouhei Yoshikawaの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第245号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3164/jcbn.17-20"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.17-20","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"343156"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉川, 亮平","creatorNameLang":"ja"},{"creatorName":"ヨシカワ, リョウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshikawa, Ryouhei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山本, 浩範","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ナカハシ, オトキ","creatorNameLang":"ja"},{"creatorName":"ナカハシ, オトキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakahashi, Otoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カガワ, トモヒロ","creatorNameLang":"ja"},{"creatorName":"カガワ, トモヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kagawa, Tomohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タジリ, マリ","creatorNameLang":"ja"},{"creatorName":"タジリ, マリ","creatorNameLang":"ja-Kana"},{"creatorName":"Tajiri, Mari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカオ, マリ","creatorNameLang":"ja"},{"creatorName":"ナカオ, マリ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakao, Mari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フクダ, シオリ","creatorNameLang":"ja"},{"creatorName":"フクダ, シオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuda, Shiori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"新井, 英一","creatorNameLang":"ja"},{"creatorName":"アライ, ヒデカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Arai, Hidekazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"増田, 真志","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"761","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イワノ, マサユキ","creatorNameLang":"ja"},{"creatorName":"イワノ, マサユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwano, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"武田, 英二","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹谷, 豊","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1585","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-01-25"}],"displaytype":"detail","filename":"k3119_abstract_review.pdf","filesize":[{"value":"303 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2004199/files/k3119_abstract_review.pdf"},"version_id":"c6202f64-d37d-482b-9bca-0208337748ef"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-02-28"}],"displaytype":"detail","filename":"k3119_fulltext.pdf","filesize":[{"value":"558 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004199/files/k3119_fulltext.pdf"},"version_id":"1229a574-ed8e-4aa3-9ba5-f72253d341e9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α-Klotho","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"age-related change","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vitamin D metabolism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inorganic phosphate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral 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associated with renal α-Klotho gene expression in mice"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T02:57:26.413108+00:00"}