{"created":"2024-10-28T03:05:51.714986+00:00","id":2004308,"links":{},"metadata":{"_buckets":{"deposit":"c7dd9f34-d099-498c-8481-4861d26dcfeb"},"_deposit":{"created_by":7,"id":"2004308","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004308"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004308","sets":["1713853213384:1713853296295:1716267876683:1716268552315"]},"author_link":["466","333","394","620","398","495","1559","354","1535"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"DAPI染色による腎アミロイドーシスの新しい鑑別方法","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Diagnosis of renal AL amyloidosis using DAPI","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"221","bibliographicPageStart":"217","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Amyloidosis is often overlooked because its clinical manifestations can mimic those of more-common diseases. It is important to get a precise diagnosis as early as possible for the prevention of further organ damages. Amyloidosis is a disorder caused by deposition of insoluble abnormal amyloid. The kidney is a frequent site of amyloid deposition. The amyloid fibrils have a characteristic appearance and generate birefringence under polarized light when stained with the Congo red dye. Classification of amyloidosis is based on the precursor protein that forms the amyloid fibrils and the distribution of amyloid deposits as either systemic or localized. Involvement of amyloid fibrils in kidneys mainly occurs as amyloid light-chain (AL) or amyloid A (AA) amyloidosis. The potassium permanganate method with Congo red staining was once used widely to discriminate AL and AA amyloidoses, but thismethod has a problem of false positive results. We found that extracellular and cytoplasmic glomerular 4’,6-diamidino-2-phenylindole (DAPI)-positive areas were clearly consistent with amyloid deposition in AL amyloidosis. In contrast, the overlapping staining was not seen in AA amyloidosis. Therefore, we propose that DAPI staining readily distinguishes AL renal amyloidosis from AA renal amyloidosis as a simple and reproducible histochemical method.  ","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Faculty of Medicine Tokushima University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第2099号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-11-30"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Motokazu Matsuuraの学位論文として提出され，学位審査・授与の対象となっている。"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"乙医第1753号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.64.217"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.64.217","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"340994"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松浦, 元一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安部, 秀斉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"333","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"冨永, 辰也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"櫻井, 明子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上, 太一","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岸, 誠司","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"495","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂東, 良美","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ミナクチ, ジュン","creatorNameLang":"ja"},{"creatorName":"ミナクチ, ジュン","creatorNameLang":"ja-Kana"},{"creatorName":"Minakuchi, Jun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"長井, 幸二郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"土井, 俊夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1535","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-01-11"}],"displaytype":"detail","filename":"o2099_abstract_review.pdf","filesize":[{"value":"333 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2004308/files/o2099_abstract_review.pdf"},"version_id":"7aa1e539-56bf-45af-88a3-870dcfcd106e"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-01-11"}],"displaytype":"detail","filename":"o2099_fulltext.pdf","filesize":[{"value":"412 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004308/files/o2099_fulltext.pdf"},"version_id":"38e9cbe0-282b-49d5-b5e8-ff4df4c8c43b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amyloidosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DAPI","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Renal amyloidosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"AL amyloidosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"AA amyloidosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A Novel Method of DAPI Staining for Differential Diagnosis of Renal Amyloidosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Novel Method of DAPI Staining for Differential Diagnosis of Renal Amyloidosis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268552315"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-03-08"},"publish_date":"2018-03-08","publish_status":"0","recid":"2004308","relation_version_is_last":true,"title":["A Novel Method of DAPI Staining for Differential Diagnosis of Renal Amyloidosis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T03:06:01.192039+00:00"}