{"created":"2024-10-28T03:06:24.506387+00:00","id":2004315,"links":{},"metadata":{"_buckets":{"deposit":"d1fa0e85-b342-4bff-a32b-42fbd0a3edb5"},"_deposit":{"created_by":7,"id":"2004315","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004315"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004315","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["631"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"5/6腎摘マウスの腎臓におけるミトコンドリア呼吸鎖複合体の不均衡","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Renal mitochondrial complex in 5/6 Nx mice","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"261","bibliographicPageStart":"255","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hyperglycemia induces nonconcordant regulation of renal mitochondrial respiratory complexes, increases oxidative stress, and causes diabetic nephropathy. Hypertension is a complication associated with diabetes and involves glomerular hyperfiltration, the effects of which on mitochondrial respiratory complexes are not well understood. To investigate the effect of glomerular hyperfiltration on renal mitochondrial respiratory complexes, we used the 5/6 nephrectomized BKS.Cg-Dock7m+/+Leprdb/J, Dock7m+/+Leprdb mice (db/m-5/6Nx mice) as a model for glomerular hyperfiltration. The BKS.Cg-Dock7m+/+Leprdb/J, +Leprdb/+Leprdb mice (db/db mice), a model for type 2 diabetes, was used as the positive control. We investigated the activities and protein levels of the mitochondrial complex, and themitochondrial DNA and adenosine triphosphate content in the kidneys of these models. Blood chemistry and renal histopathological examination were performed for characterization of the disease. Both models showed expansion of the mesangial matrix of the glomeruli, which is indicative of glomerular hyperfiltration. The activities of complexes I and IV and the protein levels of complexes I and III were nonconcordant in db/m-5/6Nx mice. In conclusion, we demonstrated that nonconcordant regulation of mitochondrial complexes in db/m-5/6Nx mice involved with glomerular hyperfiltration. The progression and/or severity of nephropathymight be affected through a synergistic effect of mitochondrial dysfunction in hyperglycemia and glomerular hyperfiltration.  ","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Faculty of Medicine Tokushima University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3137号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-02-22"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Yukie Nakashitaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院栄養生命科学教育部（人間栄養科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第246号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.64.255"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.64.255","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"341945"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中下, 幸江","creatorNameLang":"ja"},{"creatorName":"ナカシタ, ユキエ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakashita, Yukie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サノ, トモヤ","creatorNameLang":"ja"},{"creatorName":"サノ, トモヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Sano, Tomoya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヨシオカ, ヒロアキ","creatorNameLang":"ja"},{"creatorName":"ヨシオカ, ヒロアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshioka, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"シマダ, トモキ","creatorNameLang":"ja"},{"creatorName":"シマダ, トモキ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimada, Tomoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ホリ, リョウタロウ","creatorNameLang":"ja"},{"creatorName":"ホリ, リョウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Hori, Ryotaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウサミ, マコト","creatorNameLang":"ja"},{"creatorName":"ウサミ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Usami, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"濵田, 康弘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"631","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-05-17"}],"displaytype":"detail","filename":"k3137_abstract_review.pdf","filesize":[{"value":"394 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2004315/files/k3137_abstract_review.pdf"},"version_id":"d3758f2c-1dd1-4b0a-845b-fe30af1eb1b0"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-05-17"}],"displaytype":"detail","filename":"k3137_fulltext.pdf","filesize":[{"value":"575 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004315/files/k3137_fulltext.pdf"},"version_id":"2d98fffb-5bda-4e2a-8289-fde63bc7ce80"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"db/m-5/6 nephrectomized mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"db/db mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glomerular hyperfiltration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mitochondrial respiratory complex","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Nonconcordant regulation of mitochondrial respiratory complexes in the kidneys of 5/6 nephrectomized mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Nonconcordant regulation of mitochondrial respiratory complexes in the kidneys of 5/6 nephrectomized mice","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-03-08"},"publish_date":"2018-03-08","publish_status":"0","recid":"2004315","relation_version_is_last":true,"title":["Nonconcordant regulation of mitochondrial respiratory complexes in the kidneys of 5/6 nephrectomized mice"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T03:06:34.017154+00:00"}