{"created":"2024-10-28T03:08:50.723232+00:00","id":2004346,"links":{},"metadata":{"_buckets":{"deposit":"e131e2ae-06f5-4c6a-9523-3b782cf120d6"},"_deposit":{"created_by":7,"id":"2004346","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004346"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004346","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["343","844","1645"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"イソフルラン誘発性のポストコンディショニング効果はミトコンドリアのカルシウム依存性カリウムチャネルを介している","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Isoflurane actions via the mKCa channel","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"84","bibliographicPageStart":"80","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose : Activation of the mitochondrial calcium-activated potassium (mKCa) channel reportedly confers resistance to myocardial ischemic stress. However, the role of the mKCa channel in postconditioning induced by volatile anesthetic remains unclear. Methods :Male Japanese white rabbits underwent coronary artery occlusion for 30 min followed by reperfusion for 3 h. Volatile anesthetic, isoflurane, was administered at 3min prior to reperfusion for 5 min. Rabbits were injected with the mKCa channel blocker, iberiotoxin, or the mKCa channel opener, NS1619, at 8 min prior to reperfusion. Myocardial infarct size and the area at risk (AAR) were measured at the end of the experiment. Results : Isoflurane significantly reduced infarct size (23.0±9.8% of the AAR, P<0.05) compared with the control (44.0±9.1%). Iberiotoxin abolished the cardioprotective impact of isoflurane (43.0±11.6%), while iberiotoxin alone exerted no effect on infarct size (45.0±9.5%). NS1619 and isoflurane/ NS1619 both significantly reduced infarct size (21.0±10.3% and 19.0±8.8%, respectively, P<0.05 vs control group), but isoflurane/NS1619 showed no additional benefits compared with isoflurane alone. Conclusion : These results indicate that activation of the mKCa channel contribute isoflurane-induced postconditioning.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Faculty of Medicine Tokushima University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2948号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-22"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201606071002.pdf\n論文本文 : LID201606071003.pdf\n本論文は，著者Michiko Kinoshitaの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1281号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.63.80"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.63.80","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"316780"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木下, 倫子","creatorNameLang":"ja"},{"creatorName":"キノシタ, ミチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kinoshita, Michiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"堤, 保夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福田, 浩平","creatorNameLang":"ja"},{"creatorName":"フクタ, コウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuta, Kohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"笠井, 飛鳥","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"844","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 克哉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1645","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-06-07"}],"displaytype":"detail","filename":"LID201606071002.pdf","filesize":[{"value":"339 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2004346/files/LID201606071002.pdf"},"version_id":"b5a97dcf-85b5-4fac-be1b-9106f139645c"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2016-06-07"}],"displaytype":"detail","filename":"LID201606071003.pdf","filesize":[{"value":"223 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004346/files/LID201606071003.pdf"},"version_id":"2625c97d-f98e-4b66-b4ce-018afc722686"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Mitochondrial calcium-activated potassium channel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anesthetic-induced postconditioning","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Isoflurane","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-04-10"},"publish_date":"2018-04-10","publish_status":"0","recid":"2004346","relation_version_is_last":true,"title":["Isoflurane-induced postconditioning via mitochondrial calcium-activated potassium channels"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T03:09:00.906855+00:00"}