{"created":"2024-10-28T03:17:58.422715+00:00","id":2004459,"links":{},"metadata":{"_buckets":{"deposit":"c37329a5-91c0-4f32-a4f2-0978f6de0e1c"},"_deposit":{"created_by":7,"id":"2004459","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004459"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004459","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["1453","1547","345","1250","1524"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"浸潤性子宮頸癌における血管内皮増殖因子の発現と微小血管密度の重要性について","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"160","bibliographicPageStart":"154","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To determine whether vascular endothelial growth factor (VEGF) expression and microvessel density are predictive of prognosis in cases of invasive cervical cancer, correlations among VEGF expression, microvessel density, and clinicopathological parameters were identified. VEGF expression was evaluated in 50 cervical cancer samples by immunohistochemical staining. Microvessel density was assessed by immunostaining for CD31-positive endothelial cells in the most vascularized areas of tumors. VEGF expression and microvessel density were significantly higher in adenocarcinomas than in squamous cell carcinomas. However, in cases of adenocarcinoma, no significant correlations were found among VEGF expression, microvessel density, and clinicopathological parameters. In contrast, for squamous cell carcinomas, microvessel density was significantly higher in cases at an advanced stage and in those with several other poor prognostic factors. The finding that cervical adenocarcinomas exhibited greater VEGF expression and microvessel density than squamous cell carcinomas may explain the poorer prognosis of adenocarcinoma compared with squamous cell carcinoma. Moreover, microvessel density in squamous cell carcinomas was significantly correlated with poor prognostic factors. Therefore, there is possibility that bevacizumab, a humanized monoclonal antibody against VEGF-A, may be useful in the initial treatment targeting angiogenesis for early-stage cervical cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Faculty of Medicine Tokushima University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第2800号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-19"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開:\n内容要旨・審査要旨 : LID201505211003.pdf\n論文本文 : LID201505211004.pdf\n本論文は，著者Yasuyo Saijoの学位論文として提出され，学位審査・授与の対象となっている。\n西條康代の姓「西」の正確な漢字については審査要旨をご参照ください。\n学位授与者所属 : 徳島大学大学院医学研究科（外科系専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1242号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.62.154"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.62.154","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"316936"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西條, 康代","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古本, 博孝","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 加奈子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村, 正人","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1250","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"苛原, 稔","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1524","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-05-21"}],"displaytype":"detail","filename":"LID201505211003.pdf","filesize":[{"value":"180 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2004459/files/LID201505211003.pdf"},"version_id":"ceb455ac-659f-419a-8095-05bf0f2d6fa8"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2015-05-21"}],"displaytype":"detail","filename":"LID201505211004.pdf","filesize":[{"value":"2.25 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004459/files/LID201505211004.pdf"},"version_id":"ba42d1ba-a5a2-4d19-b100-c43dab963fe3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cervical cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vascular endothelial growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microvessel density","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bevacizumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"angiogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Clinical Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Invasive Cervical Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Invasive Cervical Cancer","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-05-21"},"publish_date":"2018-05-21","publish_status":"0","recid":"2004459","relation_version_is_last":true,"title":["Clinical Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Invasive Cervical Cancer"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T03:18:07.463616+00:00"}