{"created":"2024-10-28T03:20:09.154049+00:00","id":2004487,"links":{},"metadata":{"_buckets":{"deposit":"e69467b9-3cba-4e32-ac96-2e91e6816033"},"_deposit":{"created_by":7,"id":"2004487","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004487"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004487","sets":["1713829974766:1713854681789:1716364516449:1716365580232","1713853213384:1713853295607"]},"author_link":["1532","1645","1544"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"76","bibliographicPageStart":"66","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background : Hyperkalemia has multimodal effects on myocardial protection during ischemia/reperfusion. The preservation of Na+/K+-ATPase activity induced by hyperkalemia may have critical impact on myocardial protection. Methods : To elucidate the roles of hyperkalemia (16 mM) and Na+/K+-ATPase inhibition (100 μMouabain) inmyocardial protection during simulated ischemia (5 mM NaCN and 5.5 mM 2-deoxyglucose)/ reperfusion, we measured loss of membrane integrity and bleb formation using a vital dye calcein AM in cultured neonatal rat cardiomyocytes. The control perfusate was switched to treatment solution for 15 min, followed by reperfusion for 30 min. In a second set of experiments, myocardial excitability and diastolic intracellular calcium ion concentration ([Ca2+]i) were measured during a 45-min treatment using a calcium-sensitive fluorescent dye fluo-4 AM. Results : Simulated ischemia/reperfusion under ouabain treatment induced loss of membrane integrity, which was suppressed by hyperkalemia. Simulated ischemia/reperfusion induced bleb formation, which was accelerated by ouabain. Hyperkalemia delayed and inhibited the increase in diastolic [Ca2+]i induced by simulated ischemia. Furthermore, hyperkalemia almost completely inhibited the effects of ouabain on the diastolic [Ca2+]i during ischemia. Conclusions : These results suggest that hyperkalemia during ischemia is cardioprotective against ischemia/reperfusion insults and that hyperkalemia inhibits the effects of ouabain during ischemia.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Faculty of Medicine Tokushima University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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