{"created":"2024-10-28T03:21:11.209354+00:00","id":2004500,"links":{},"metadata":{"_buckets":{"deposit":"b89e6c19-735c-45e4-83c2-105204dbf63c"},"_deposit":{"created_by":7,"id":"2004500","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004500"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004500","sets":["1713829974766:1713854681789:1716364517711:1716365817658","1713853213384:1713853295607"]},"author_link":["310","1523","1559","189","1530","1548"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"98","bibliographicPageStart":"93","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Long-Evans Cinnamon (LEC) rat, an animal model of Wilson’s disease, is resistant to a variety of chemical carcinogenesis except liver and colon. In the present study, N-ethyl-N-nitrosourea (ENU)-induced transplacental carcinogenesis was examined in male and female LEC, Long-Evans Agouti (LEA), a sibling line of the LEC rat, and F344 rats (n=21). ENU was administered to pregnant rats as a single s.c. injection at a dose of 60 mg/kg body weight on the 17th day after conception. Cerebral/spinal gliomas and trigeminal/spinal nerve schwannomas developed in both LEA and F344 rats at 30 weeks of age, but no nervous system tumors developed in LEC rats, the difference being statistically significant. Lung adenomas also developed in LEA and F344 rats, but not in LEC rats. Semiquantitative RT-PCR demonstrated that metallothionein (MT)1a, MT2 and O6-methylguanine-DNA methyltransferase (MGMT) mRNA levels in the liver of LEC rats were higher than those in F344 and LEA rats. In addition, Western blot analysis showed that MT (MT1 plus MT2) in the liver of LEC rats was also higher than that in other strains. Present results suggest that high levels of MT and/or MGMT contribute to the resistance to nitrosamine-induced carcinogenesis in LEC rats.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Faculty of Medicine Tokushima University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.56.93"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.56.93","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"224162"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ツチガウチ, タケシ","creatorNameLang":"ja"},{"creatorName":"ツチガウチ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuchigauchi, Takeshi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"高橋, 徹行","creatorNameLang":"ja"},{"creatorName":"タカハシ, テツユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Tetsuyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"高橋","familyNameLang":"ja"},{"familyName":"タカハシ","familyNameLang":"ja-Kana"},{"familyName":"Takahashi","familyNameLang":"en"}],"givenNames":[{"givenName":"徹行","givenNameLang":"ja"},{"givenName":"テツユキ","givenNameLang":"ja-Kana"},{"givenName":"Tetsuyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"189","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00403692","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00403692"}]},{"creatorNames":[{"creatorName":"オオニシ, タカマサ","creatorNameLang":"ja"},{"creatorName":"オオニシ, タカマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohnishi, Takamasa","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"小川, 博久","creatorNameLang":"ja"},{"creatorName":"オガワ, ヒロヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ogawa, Hirohisa","creatorNameLang":"en"}],"familyNames":[{"familyName":"小川","familyNameLang":"ja"},{"familyName":"オガワ","familyNameLang":"ja-Kana"},{"familyName":"Ogawa","familyNameLang":"en"}],"givenNames":[{"givenName":"博久","givenNameLang":"ja"},{"givenName":"ヒロヒサ","givenNameLang":"ja-Kana"},{"givenName":"Hirohisa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"310","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"174041/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/174041/profile-ja.html"},{"nameIdentifier":"50403754","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50403754"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"坂東, 良美","creatorNameLang":"ja"},{"creatorName":"バンドウ, ヨシミ","creatorNameLang":"ja-Kana"},{"creatorName":"Bando, Yoshimi","creatorNameLang":"en"}],"familyNames":[{"familyName":"坂東","familyNameLang":"ja"},{"familyName":"バンドウ","familyNameLang":"ja-Kana"},{"familyName":"Bando","familyNameLang":"en"}],"givenNames":[{"givenName":"良美","givenNameLang":"ja"},{"givenName":"ヨシミ","givenNameLang":"ja-Kana"},{"givenName":"Yoshimi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1559","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60096/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60096/profile-ja.html"},{"nameIdentifier":"00238239","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00238239"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"上原, 久典","creatorNameLang":"ja"},{"creatorName":"ウエハラ, ヒサノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Uehara, Hisanori","creatorNameLang":"en"}],"familyNames":[{"familyName":"上原","familyNameLang":"ja"},{"familyName":"ウエハラ","familyNameLang":"ja-Kana"},{"familyName":"Uehara","familyNameLang":"en"}],"givenNames":[{"givenName":"久典","givenNameLang":"ja"},{"givenName":"ヒサノリ","givenNameLang":"ja-Kana"},{"givenName":"Hisanori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1548","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60072/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60072/profile-ja.html"},{"nameIdentifier":"30263809","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30263809"}]},{"creatorNames":[{"creatorName":"タキザワ, タモツ","creatorNameLang":"ja"},{"creatorName":"タキザワ, タモツ","creatorNameLang":"ja-Kana"},{"creatorName":"Takizawa, Tamotsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カネダ, シンヤ","creatorNameLang":"ja"},{"creatorName":"カネダ, シンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Kaneda, Shinya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカイ, トキコ","creatorNameLang":"ja"},{"creatorName":"ナカイ, トキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakai, Tokiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"塩田, 洋","creatorNameLang":"ja"},{"creatorName":"シオタ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Shiota, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"塩田","familyNameLang":"ja"},{"familyName":"シオタ","familyNameLang":"ja-Kana"},{"familyName":"Shiota","familyNameLang":"en"}],"givenNames":[{"givenName":"洋","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"},{"givenName":"Hiroshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1523","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60035/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60035/profile-ja.html"},{"nameIdentifier":"20035736","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20035736"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"泉, 啓介","creatorNameLang":"ja"},{"creatorName":"イズミ, ケイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Izumi, Keisuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"泉","familyNameLang":"ja"},{"familyName":"イズミ","familyNameLang":"ja-Kana"},{"familyName":"Izumi","familyNameLang":"en"}],"givenNames":[{"givenName":"啓介","givenNameLang":"ja"},{"givenName":"ケイスケ","givenNameLang":"ja-Kana"},{"givenName":"Keisuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1530","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60043/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60043/profile-ja.html"},{"nameIdentifier":"30116777","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30116777"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-05-22"}],"displaytype":"detail","filename":"jmi_56_3-4_93.pdf","filesize":[{"value":"620 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004500/files/jmi_56_3-4_93.pdf"},"version_id":"309f1337-b1b3-44b0-ac4e-81afc1578225"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Long-Evans Cinnamon rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Long-Evans Agouti rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"N-ethyl-N-nitrosourea","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"trigeminal schwannoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metallothionein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"O6-methylduanine-DNA methyltransferase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Low susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Low susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607","1716365817658"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-05-22"},"publish_date":"2018-05-22","publish_status":"0","recid":"2004500","relation_version_is_last":true,"title":["Low susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T04:42:18.267270+00:00"}