{"created":"2024-10-28T03:24:15.906643+00:00","id":2004544,"links":{},"metadata":{"_buckets":{"deposit":"50c15438-9e1d-4761-ad8b-c20a38d807a5"},"_deposit":{"created_by":7,"id":"2004544","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004544"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004544","sets":["1713853213384:1713853629798"]},"author_link":[],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"301","bibliographicPageStart":"301","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Distal colonic K+ excretion is determined by the balance of K+ absorption and K+ secretion of the enterocytes. K+ secretion occurs via active basolateral K+ uptake mostly via the NKCC1 co-transporter followed by K+ exit via a luminal K+ channel. The specific focus here is directed towards the luminal secretory K+ channel (1). Several recent observations highlight the pivotal role of the large conductance, Ca2+-activated KCa1.1 (BK, KCNMA) channel as the only functionally relevant luminal K+ efflux pathway in mouse distal colon (2, 3). This conclusion was based on defining results from BK knock-out mice. The following key observations were made : 1. BK channels mediate the resting distal colonic K+ secretion (2, 4), 2. They are acutely stimulated by activation of luminal nucleotide receptor and elevations of intracellular Ca2+ (2, 4, 5), 3. Colonic BK channels are up-regulated by increases of plasma aldosterone (3), 4. In addition, the cAMP-stimulated distal colonic K+ secretion is apparently mediated via BK channels, 5. Finally, aldosterone was found to up-regulate specifically the ZERO (e.g. cAMP activated) C-terminal splice variant of the BK channel. In summary, we suggest that the sole exit pathway for transcellular K+ secretion in mammalian distal colon is the BK channel, which is the target for short term intracellular Ca2+ and cAMP activation and long term aldosterone regulation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Faculty of Medicine Tokushima University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.56.301"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.56.301","subitem_relation_type_select":"DOI"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sörensen, Mads V","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Leipziger, Jens","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-06-07"}],"displaytype":"detail","filename":"jmi_56_suppl_301.pdf","filesize":[{"value":"39.9 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004544/files/jmi_56_suppl_301.pdf"},"version_id":"5a617cb4-d89a-4e66-9e40-10d5d27c7419"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"K+ channel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ion secretion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"colon","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epithelium","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"The essential role of luminal BK channels in distal colonic K+ secretion","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The essential role of luminal BK channels in distal colonic K+ secretion","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853629798"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-07"},"publish_date":"2018-06-07","publish_status":"0","recid":"2004544","relation_version_is_last":true,"title":["The essential role of luminal BK channels in distal colonic K+ secretion"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-10-28T03:24:22.787072+00:00"}