{"created":"2024-10-28T03:27:17.310773+00:00","id":2004586,"links":{},"metadata":{"_buckets":{"deposit":"aae034fd-b390-4d72-97e9-7f86635df4d2"},"_deposit":{"created_by":7,"id":"2004586","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004586"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004586","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["391","1184","173"],"control_number":"2004586","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"クラリスロマイシンはインフルエンザAウイルスに感染したマウスにおいて、monocyte chemoattractant protein-1とmatrix metalloproteinase-9の発現誘導を抑制し、肺と心臓における病理学的変化を改善する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-11-23","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"13","bibliographicPageStart":"6","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"Comparative Immunology, Microbiology and Infectious Diseases","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The influenza A virus (IAV)–cytokine–trypsin/matrix metalloproteinase-9 (MMP-9) cycle is one of the important mechanisms of multiple organ failure in severe influenza. Clarithromycin, a macrolide antibiotic, has immune modulatory and anti-inflammatory effects. We analyzed the effects of clarithromycin on the induction of chemokines, cytokines, MMP-9, trypsin, vascular hyper-permeability and inflammatory aggravation in mice with IAV infection. IAV/Puerto Rico/8/34(H1N1) infection increased the levels of monocyte chemoattractant protein- 1 (MCP-1) and cytokines in serum, and MMP-9 and trypsin in serum and/or the lungs and heart. Clarithromycin significantly suppressed the induction of serum MCP-1 and MMP-9 and vascular hyperpermeability in these organs in the early phase of infection, but did not suppress the induction of trypsin, IL-6 or IFN-γ. Histopathological examination showed that clarithromycin tended to reduce inflammatory cell accumulation in the lungs and heart. These results suggest that clarithromycin suppresses infection-related inflammation and reduces vascular hyperpermeability by suppressing the induction of MCP-1 and MMP-9.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"01479571","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11644419","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA00612035","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3122号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-01-25"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は, 著者Etsuhisa Takahashiの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1356号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.cimid.2017.11.002"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.cimid.2017.11.002","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"356463"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 悦久","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Indalao, Irene L.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サワブチ, タカコ","creatorNameLang":"ja"},{"creatorName":"サワブチ, タカコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sawabuchi, Takako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミズノ, ケイコ","creatorNameLang":"ja"},{"creatorName":"ミズノ, ケイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Mizuno, Keiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サカイ, サトコ","creatorNameLang":"ja"},{"creatorName":"サカイ, サトコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakai, Satoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"木本, 貴士","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1184","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kim, Hyejin","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"木戸, 博","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"173","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-04-13"}],"displaytype":"detail","filename":"k3122_abstract_review.pdf","filesize":[{"value":"336 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2004586/files/k3122_abstract_review.pdf"},"version_id":"c5246980-eb8f-4664-adae-e5a9c431bacd"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-04-13"}],"displaytype":"detail","filename":"k3122_fulltext.pdf","filesize":[{"value":"1.19 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004586/files/k3122_fulltext.pdf"},"version_id":"c7fedffa-f647-4da8-b494-c10e4160772a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Matrix metalloproteinase-9","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Macrolide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Clarithromycin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Influenza A virus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Multiple organ failure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Evans’ blue extravasation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Influenza A virus infection","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-04-13"},"publish_date":"2018-04-13","publish_status":"0","recid":"2004586","relation_version_is_last":true,"title":["Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-13T02:44:28.013957+00:00"}