{"created":"2024-10-28T03:29:33.663194+00:00","id":2004616,"links":{},"metadata":{"_buckets":{"deposit":"18663fd7-545d-4df9-8b57-53834ef62fb7"},"_deposit":{"created_by":7,"id":"2004616","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004616"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004616","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["426"],"control_number":"2004616","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Edaravoneによる正常眼圧緑内障モデルマウスの網膜神経節細胞死の抑制","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Edaravone prevents normal tension glaucoma","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-07-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"e2934","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Cell Death & Disease","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Glaucoma, one of the leading causes of irreversible blindness, is characterized by progressive degeneration of optic nerves and retinal ganglion cells (RGCs). In the mammalian retina, excitatory amino-acid carrier 1 (EAAC1) is expressed in neural cells, including RGCs. Loss of EAAC1 leads to RGC degeneration without elevated intraocular pressure (IOP) and exhibits glaucomatous pathology including glutamate neurotoxicity and oxidative stress. In the present study, we found that edaravone, a free radical scavenger that is used for treatment of acute brain infarction and amyotrophic lateral sclerosis (ALS), reduces oxidative stress and prevents RGC death and thinning of the inner retinal layer in EAAC1-deficient (KO) mice. In addition, in vivo electrophysiological analyses demonstrated that visual impairment in EAAC1 KO mice was ameliorated with edaravone treatment, clearly establishing that edaravone beneficially affects both histological and functional aspects of the glaucomatous retina. Our findings raise intriguing possibilities for the management of glaucoma by utilizing a widely prescribed drug for the treatment of acute brain infarction and ALS, edaravone, in combination with conventional treatments to lower IOP.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20414889","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3126号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は, 著者Kei Akaiwaの学位論文として提出され, 学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部(医学専攻)"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1360号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/cddis.2017.341"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/cddis.2017.341","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"337796"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"赤岩, 慶","creatorNameLang":"ja"},{"creatorName":"アカイワ, ケイ","creatorNameLang":"ja-Kana"},{"creatorName":"Akaiwa, Kei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナメカタ, カズヒコ","creatorNameLang":"ja"},{"creatorName":"ナメカタ, カズヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Namekata, Kazuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アズチ, ユリコ","creatorNameLang":"ja"},{"creatorName":"アズチ, ユリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Azuchi, Yuriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Guo, Xiaoli","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キムラ, アツコ","creatorNameLang":"ja"},{"creatorName":"キムラ, アツコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kimura, Atsuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハラダ, チカコ","creatorNameLang":"ja"},{"creatorName":"ハラダ, チカコ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Chikako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"三田村, 佳典","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"426","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ハラダ, タカユキ","creatorNameLang":"ja"},{"creatorName":"ハラダ, タカユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Takayuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"k3126_abstract_review.pdf","filesize":[{"value":"365 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2004616/files/k3126_abstract_review.pdf"},"version_id":"d42a9610-1f0e-484f-a1fe-2a8e46602252"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"k3126_fulltext.pdf","filesize":[{"value":"1.69 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