{"created":"2024-10-28T03:30:07.371301+00:00","id":2004622,"links":{},"metadata":{"_buckets":{"deposit":"12261d98-2421-47bf-8fc7-cd16e13fbd94"},"_deposit":{"created_by":7,"id":"2004622","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004622"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004622","sets":["1713829974766:1713854681789:1716364514624:1716365318296","1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["392","1581","546"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"ゲラニルゲラニルアセトンはマウスにおいてストレスによるレプチン分泌の減少を防ぐ","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"GGA and leptin secretion","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"109","bibliographicPageStart":"103","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Geranylgeranylacetone (GGA) is a chaperon inducer that protects various types of cell and tissue against stress. We examined whether GGA modulated energy intake and expenditure under stressful conditions. After mice were untreated or treated orally with GGA (0.16 g per kg body weight per day) for 10 days, they were subjected to 2-h restraint stress once or once a day for 5 consecutive days. GGA administration did not affect corticosterone response to the stress. Restraint stress rapidly decreased plasma leptin levels in control mice. GGA significantly increased circulating leptin levels without changing food intake and prevented the stress-induced decline of circulating leptin. However GGA-treated mice significantly reduced food intake during the repeated stress, compared with control mice. GGA prevented the stress-induced decline of leptin mRNA and its protein levels in epidydimal adipose tissues. We also found that GGA decreased ghrelin mRNA expression in gastric mucosa before the stress, whereas GGA-treated mice recovered the ghrelin mRNA expression to the baseline level after the repeated stress. Leptin and ghrelin are now recognized as regulators of anxiety and depressive mood. Our results suggest that GGA may regulate food intake and relief stress-induced mood disturbance through regulating leptin and ghrelin secretions.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Faculty of Medicine Tokushima University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13496867","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"13431420","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12022913","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3136号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-23"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Miki Itaiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科学教育部（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1370号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.2152/jmi.65.103"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2152/jmi.65.103","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"344574"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"板井, 美樹","creatorNameLang":"ja"},{"creatorName":"イタイ, ミキ","creatorNameLang":"ja-Kana"},{"creatorName":"Itai, Miki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"桑野, 由紀","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西川, 達哉","creatorNameLang":"ja"},{"creatorName":"ニシカワ, タツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishikawa, Tatsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"六反, 一仁","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西田, 憲生","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"546","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"k3136_abstract_review.pdf","filesize":[{"value":"324 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2004622/files/k3136_abstract_review.pdf"},"version_id":"91214444-408e-41ba-94d2-8dd810fe354d"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"k3136_fulltext.pdf","filesize":[{"value":"1.98 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2004622/files/k3136_fulltext.pdf"},"version_id":"fbfebc70-8811-4ab0-bb4d-51ef9d5a2287"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Geranylgeranylacetone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"food intake","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"leptin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ghrelin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Geranylgeranylacetone prevents stress-induced decline of leptin secretion in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Geranylgeranylacetone prevents stress-induced decline of leptin secretion in mice","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628","1716365318296"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-04-27"},"publish_date":"2018-04-27","publish_status":"0","recid":"2004622","relation_version_is_last":true,"title":["Geranylgeranylacetone prevents stress-induced decline of leptin secretion in mice"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-20T05:02:57.092300+00:00"}