{"created":"2024-10-28T05:29:10.074359+00:00","id":2004641,"links":{},"metadata":{"_buckets":{"deposit":"efa80375-548c-4b68-9fe3-6a4f8e7c2240"},"_deposit":{"created_by":7,"id":"2004641","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2004641"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02004641","sets":["1713853213384:1713853295607"]},"author_link":["1648","174","1527","185"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"TWO PITUITARY ADENOMAS IN MEN 1","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"340","bibliographicPageStart":"331","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Endocrine Journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The clinical and genetic features of a 43-year-old male patient with multiple endocrine neoplasia type 1 were reported. He developed hyperparathyroidism, a GHRH-producing pancreatic tumor, and acromegaly between 1980 and 1983. Because his pituitary gland increased in size even after resecting the GHRH-producing pancreatic tumor, transsphenoidal hypophysectomy was performed six years later. The pituitary contained two histologically-different adenomas composed of somatotroph cells and null cells. Genetic analyses revealed loss of heterozygosity on chromosome 11 in common in the pituitary adenomas, the pancreatic endocrine tumors, and a parathyroid hyperplasia. On the other hand, mutations of ras, p53, Gsα, and Gi2α genes were not found in these tumors. The loss of the tumor suppressor gene on chromosome 11q12-13 was involved in the formation of two pituitary adenomas, two pancreatic endocrine functioning tumors, and a parathyroid hyperplasia in this patient, but the tumorigenic factors in the specific endocrine organs remain to be studied.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Endocrine 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1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pituitary adenoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ectopic GHRH-producing tumor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Loss of heterozygosity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chromosome 11","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Two Different Pituitary Adenomas in a Patient with Multiple Endocrine Neoplasia Type 1 Associated with Growth Hormone-Releasing Hormone-Producing Pancreatic Tumor : Clinical and Genetic Features","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Two Different Pituitary Adenomas in a Patient with Multiple Endocrine Neoplasia Type 1 Associated with Growth Hormone-Releasing Hormone-Producing Pancreatic Tumor : Clinical and Genetic Features","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-05-14"},"publish_date":"2018-05-14","publish_status":"0","recid":"2004641","relation_version_is_last":true,"title":["Two Different Pituitary Adenomas in a Patient with Multiple Endocrine Neoplasia Type 1 Associated with Growth Hormone-Releasing Hormone-Producing Pancreatic Tumor : Clinical and Genetic Features"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T06:02:31.689021+00:00"}